About: Nonribosomal cyclic peptides: specific markers

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	V tomto přehledném článku je originálně navrženo použít cyklické peptidy jako specifické markery houbových infekcí. Hlavní myšlenka práce je založena na faktu, ze neribozomální cyklické peptidy jsou produkovány pouze houbami, bakteriemi, některými rostinami a mořskými živočichy. Nejsou známy molekuly tohoto typu, které by byly popsány v savcích. Znamená to, že pokud je cyklický neribozomální peptid nalezen v krvi/tkáni/moči člověka nebo zvířete, může to ukazovat na infekci vyvolanou mikroorganismem, který produkuje příslušný metabolit (cs) Some cyclic peptides and depsipeptides are synthesized in microorganisms by large multienzymes called nonribosomal peptide synthetases. The structures of peptide products originating in this way are complex and diverse and are microorganism-specific. This work proposes the use of fungal cyclic peptides and depsipeptides as extremely specific markers of fungal infections. Since a reliable molecular tool for diagnosing fungal infections at an early stage is still missing, we present mass spectrometry as a new, modern, broadband (with respect to fungal strain) and specific tool for clinical mycologists. More than 40 different fungal species can be rapidly characterized according to specific families of cyclic peptides, and in some cases, a particular fungal strain can be identified on the basis of its cyclopeptide profile. Some cyclic peptides and depsipeptides are synthesized in microorganisms by large multienzymes called nonribosomal peptide synthetases. The structures of peptide products originating in this way are complex and diverse and are microorganism-specific. This work proposes the use of fungal cyclic peptides and depsipeptides as extremely specific markers of fungal infections. Since a reliable molecular tool for diagnosing fungal infections at an early stage is still missing, we present mass spectrometry as a new, modern, broadband (with respect to fungal strain) and specific tool for clinical mycologists. More than 40 different fungal species can be rapidly characterized according to specific families of cyclic peptides, and in some cases, a particular fungal strain can be identified on the basis of its cyclopeptide profile. (en)
Title	Nonribosomal cyclic peptides: specific markers Neribozomální cyklické peptidy jako markery houbových infekcí (cs) Nonribosomal cyclic peptides: specific markers (en)
skos:prefLabel	Nonribosomal cyclic peptides: specific markers Neribozomální cyklické peptidy jako markery houbových infekcí (cs) Nonribosomal cyclic peptides: specific markers (en)
skos:notation	RIV/61388971:_____/06:00040409!RIV07-GA0-61388971
http://linked.open.../vavai/riv/strany	563;576
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/04/0799), P(GP203/05/P575), P(LC545), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Havlíček, Vladimír Šulc, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	488871
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/06:00040409
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cyclic peptides; fungal infections; mass spectrometry (en)
http://linked.open.../riv/klicoveSlovo	mass spectrometry cyclic peptides fungal infections
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[41AB261C588E]
http://linked.open...i/riv/nazevZdroje	Journal of Mass Spectrometry
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Functional Organisation of the Cell Cyclic peptides on fungal spores - isolation, structure, immunomodulating activity Fast fungal spore characterisation by mass spectrometry
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	41
http://linked.open...iv/tvurceVysledku	Šulc, Miroslav Havlíček, Vladimír Hajdúch, M. Jegorov, A.
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology
issn	1076-5174
number of pages	14 (xsd:int)

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