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rdf:type
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Description
| - V tomto přehledném článku je originálně navrženo použít cyklické peptidy jako specifické markery houbových infekcí. Hlavní myšlenka práce je založena na faktu, ze neribozomální cyklické peptidy jsou produkovány pouze houbami, bakteriemi, některými rostinami a mořskými živočichy. Nejsou známy molekuly tohoto typu, které by byly popsány v savcích. Znamená to, že pokud je cyklický neribozomální peptid nalezen v krvi/tkáni/moči člověka nebo zvířete, může to ukazovat na infekci vyvolanou mikroorganismem, který produkuje příslušný metabolit (cs)
- Some cyclic peptides and depsipeptides are synthesized in microorganisms by large multienzymes called nonribosomal peptide synthetases. The structures of peptide products originating in this way are complex and diverse and are microorganism-specific. This work proposes the use of fungal cyclic peptides and depsipeptides as extremely specific markers of fungal infections. Since a reliable molecular tool for diagnosing fungal infections at an early stage is still missing, we present mass spectrometry as a new, modern, broadband (with respect to fungal strain) and specific tool for clinical mycologists. More than 40 different fungal species can be rapidly characterized according to specific families of cyclic peptides, and in some cases, a particular fungal strain can be identified on the basis of its cyclopeptide profile.
- Some cyclic peptides and depsipeptides are synthesized in microorganisms by large multienzymes called nonribosomal peptide synthetases. The structures of peptide products originating in this way are complex and diverse and are microorganism-specific. This work proposes the use of fungal cyclic peptides and depsipeptides as extremely specific markers of fungal infections. Since a reliable molecular tool for diagnosing fungal infections at an early stage is still missing, we present mass spectrometry as a new, modern, broadband (with respect to fungal strain) and specific tool for clinical mycologists. More than 40 different fungal species can be rapidly characterized according to specific families of cyclic peptides, and in some cases, a particular fungal strain can be identified on the basis of its cyclopeptide profile. (en)
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Title
| - Nonribosomal cyclic peptides: specific markers
- Neribozomální cyklické peptidy jako markery houbových infekcí (cs)
- Nonribosomal cyclic peptides: specific markers (en)
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skos:prefLabel
| - Nonribosomal cyclic peptides: specific markers
- Neribozomální cyklické peptidy jako markery houbových infekcí (cs)
- Nonribosomal cyclic peptides: specific markers (en)
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skos:notation
| - RIV/61388971:_____/06:00040409!RIV07-GA0-61388971
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA203/04/0799), P(GP203/05/P575), P(LC545), Z(AV0Z50200510)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61388971:_____/06:00040409
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - cyclic peptides; fungal infections; mass spectrometry (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Journal of Mass Spectrometry
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Šulc, Miroslav
- Havlíček, Vladimír
- Hajdúch, M.
- Jegorov, A.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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