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Description
  • Studie popisuje mechanismus, jakým ATP-dependentní mitochondriální Lon proteasa zahajuje proteolýzu svých substrátů. K popisu byly použity dva substráty se známou strukturou: alfa podjednotka mitochondriální procesující peptidasy a steroidogenní akutní regulační protein. Byly identifikovány postupně vznikající peptidy a mapovány vzhledem k primární, sekundární a terciární struktuře substrátu.Bylo zjištěno, že proteolýza je zahajována mezi hydrofobními aminokyselinami umístěnými ve vysoce nabitém okolí poblíž povrchu složeného proteinu (cs)
  • Mechanistic studies of ATP-dependent proteolysis demonstrate that substrate unfolding is a prerequisite for processive peptide bond hydrolysis. We show that mitochondrial Lon also degrades folded proteins and initiates substrate cleavage non-processively. Two mitochondrial substrates with known or homology-derived three-dimensional structures were used: the mitochondrial processing peptidase alpha-subunit (MPPalpha) and the steroidogenic acute regulatory protein (StAR). Peptides generated during a time course of Lon-mediated proteolysis were identified and mapped within the primary, secondary, and tertiary structure of the substrate
  • Mechanistic studies of ATP-dependent proteolysis demonstrate that substrate unfolding is a prerequisite for processive peptide bond hydrolysis. We show that mitochondrial Lon also degrades folded proteins and initiates substrate cleavage non-processively. Two mitochondrial substrates with known or homology-derived three-dimensional structures were used: the mitochondrial processing peptidase alpha-subunit (MPPalpha) and the steroidogenic acute regulatory protein (StAR). Peptides generated during a time course of Lon-mediated proteolysis were identified and mapped within the primary, secondary, and tertiary structure of the substrate (en)
Title
  • Cleavage site selection within a folded substrate by the ATP-dependent lon protease
  • Výběr cílového místa štěpení ATP-závislou lon proteasou u složeného substrátu (cs)
  • Cleavage site selection within a folded substrate by the ATP-dependent lon protease (en)
skos:prefLabel
  • Cleavage site selection within a folded substrate by the ATP-dependent lon protease
  • Výběr cílového místa štěpení ATP-závislou lon proteasou u složeného substrátu (cs)
  • Cleavage site selection within a folded substrate by the ATP-dependent lon protease (en)
skos:notation
  • RIV/61388971:_____/05:00028010!RIV06-AV0-61388971
http://linked.open.../vavai/riv/strany
  • 25103;25110
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika
  • 26
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 515493
http://linked.open...ai/riv/idVysledku
  • RIV/61388971:_____/05:00028010
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • lon protease; peptidase; proteolysis (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [E31247B736B9]
http://linked.open...i/riv/nazevZdroje
  • Journal of Biological Chemistry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 280
http://linked.open...iv/tvurceVysledku
  • Li, H.
  • Janata, Jiří
  • Gakh, Alexander
  • Liu, T.
  • Kutejová, E.
  • Ondrovičová, G.
  • Suzuki, C. K.
  • Singh, K.
  • Granot, Z.
  • Orly, J.
  • Perečko, D.
  • Tian, B.
http://linked.open...n/vavai/riv/zamer
issn
  • 0021-9258
number of pages
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