About: Effects of D2-dopamine and alfa-adrenoceptor antagonists in stress induced changes on immune reponsiveness of mice

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	%22Zapojení katecholaminových receptorů (alfa-adrenergní, D2-dopaminové) bylo studováno u stresovaných experimentálních zvířat. Stres vyvolal změněné imunitní odpovědi spojené se změnami signalizace G-proteiny, poškození TH1/TH2 cytokinové sítě a funkce buněk NK. Po aplikaci specifických antagonistů předcházející vyvolání stresu došlo k odstranění imunosuprese. D2–typ dopaminergní mechanismus representuje dominantní komponentu v regulaci Galfas/Galfai (1,2)Galfaq/11 -proteinu přenášejícího signál a fungujícího na obou -nervové a imunitní úrovni. S G-proteiny spojené receptory (GPCRs) mohou modulovat produkci cytokinů a hrát regulační úlohu v efektorových mechanismech imunity. (cs) The involvement of catecholamine receptors (alpha-adrenergic, D2-dopamine) was investigated in restraint animals. Stress influenced immune responses with concomitant changes of G-protein signal transduction. Impairment of TH1/TH2 cytokine network and natural killer (NK) cell function was observed. In vivo administration of specific antagonists prior to restraint stress reversed the immunosuppression. D2-type dopaminergic mechanism represents a dominant component in regulation of Galphas/Galphai(1,2)/Galphaq/11-protein signal transduction at level of both central nervous and immune systems. G-protein-coupled receptors (GPCRs) can modulate cytokine production and may play a regulatory role in immune effector mechanisms. The involvement of catecholamine receptors (alpha-adrenergic, D2-dopamine) was investigated in restraint animals. Stress influenced immune responses with concomitant changes of G-protein signal transduction. Impairment of TH1/TH2 cytokine network and natural killer (NK) cell function was observed. In vivo administration of specific antagonists prior to restraint stress reversed the immunosuppression. D2-type dopaminergic mechanism represents a dominant component in regulation of Galphas/Galphai(1,2)/Galphaq/11-protein signal transduction at level of both central nervous and immune systems. G-protein-coupled receptors (GPCRs) can modulate cytokine production and may play a regulatory role in immune effector mechanisms. (en)
Title	Effects of D2-dopamine and alfa-adrenoceptor antagonists in stress induced changes on immune reponsiveness of mice Effects of D2-dopamine and alfa-adrenoceptor antagonists in stress induced changes on immune reponsiveness of mice (en) Účinek D2-dopaminových a alfa-adrenergních antagonistů na stresem indukované změny imunitní odpovedi u myší (cs)
skos:prefLabel	Effects of D2-dopamine and alfa-adrenoceptor antagonists in stress induced changes on immune reponsiveness of mice Effects of D2-dopamine and alfa-adrenoceptor antagonists in stress induced changes on immune reponsiveness of mice (en) Účinek D2-dopaminových a alfa-adrenergních antagonistů na stresem indukované změny imunitní odpovedi u myší (cs)
skos:notation	RIV/61388971:_____/02:00100411!RIV/2005/AV0/A53005/N
http://linked.open.../vavai/riv/strany	55;65
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA304/01/0850), P(GA310/98/0347), P(GV312/98/K034), Z(AV0Z5020903)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Vannucci, Luca Pospíšil, Miloslav Fišerová, Anna
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	644405
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/02:00100411
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	restraint stress; cytokine; nk cell (en)
http://linked.open.../riv/klicoveSlovo	restraint stress nk cell cytokine
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[640F66A6C277]
http://linked.open...i/riv/nazevZdroje	Journal of Neuroimmunology
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Ontogenetic development of immune systém cdells and their surface structures The dopamine and prolactin role during tumor progression and immunomodulatory effect of dopaminergic ergot alkaloids. The immune recognition of cytotoxic lymphocytes: strategies for cancer immunotherapy
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	130
http://linked.open...iv/tvurceVysledku	Vannucci, Luca Kovářů, H. Fišerová, Anna Starec, M. Kuldová, M. Pospíšil, Miloslav Páv, M.
http://linked.open...n/vavai/riv/zamer	Výzkum buněčné a molekulární biologie, genetiky, fyziologie a ekologie mikroorganizmů, mikrobní biotechnologie; studium imunitních procesů
issn	0165-5728
number of pages	11 (xsd:int)

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