About: Nanodiamonds as Intracellular Probes for Imaging in Biology and Medicine

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In recent years, diamond nanoparticles have received a great deal of attention due to their unique photophysical and biological properties. Nanodiamonds (NDs) show low toxicity and are considered to be a highly biocompatible carbon nanomaterial useful in a wide range of applications. Thanks to their ability to accommodate nitrogen-vacancy (N-V) color centers, NDs are a prime example of non-photobleachable fluorescent labels and nanosensors. Here, we present a survey of ND applications in biology and medicine with an emphasis on bioimaging. We focus on distinguishing the properties of detonation NDs and high-pressure high-temperature (HPHT) NDs and describing their physicochemical properties, structure and possible modifications by small molecules and biomolecules. We summarize and critically evaluate in vitro and in vivo data on ND toxicity and biocompatibility, cellular internalization, localization and targeting by surface-attached ligands. We discuss current achievements in bioimaging using fluorescent NDs and the potential of NDs in diagnostics and drug delivery. In recent years, diamond nanoparticles have received a great deal of attention due to their unique photophysical and biological properties. Nanodiamonds (NDs) show low toxicity and are considered to be a highly biocompatible carbon nanomaterial useful in a wide range of applications. Thanks to their ability to accommodate nitrogen-vacancy (N-V) color centers, NDs are a prime example of non-photobleachable fluorescent labels and nanosensors. Here, we present a survey of ND applications in biology and medicine with an emphasis on bioimaging. We focus on distinguishing the properties of detonation NDs and high-pressure high-temperature (HPHT) NDs and describing their physicochemical properties, structure and possible modifications by small molecules and biomolecules. We summarize and critically evaluate in vitro and in vivo data on ND toxicity and biocompatibility, cellular internalization, localization and targeting by surface-attached ligands. We discuss current achievements in bioimaging using fluorescent NDs and the potential of NDs in diagnostics and drug delivery. (en)
Title	Nanodiamonds as Intracellular Probes for Imaging in Biology and Medicine Nanodiamonds as Intracellular Probes for Imaging in Biology and Medicine (en)
skos:prefLabel	Nanodiamonds as Intracellular Probes for Imaging in Biology and Medicine Nanodiamonds as Intracellular Probes for Imaging in Biology and Medicine (en)
skos:notation	RIV/61388963:_____/14:00441403!RIV15-AV0-61388963
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Cígler, Petr Raabová, Helena Řehoř, Ivan Mrázková, Eva Šlegerová, Jitka Havlík, Jan
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	31497
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/14:00441403
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	nanodiamond; fluorescence; nitrogen-vacancy center; intracellular probe; bioimaging; biocompatibility (en)
http://linked.open.../riv/klicoveSlovo	bioimaging nanodiamond nitrogen-vacancy center fluorescence biocompatibility intracellular probe
http://linked.open...ontrolniKodProRIV	[4A2551C9BDA8]
http://linked.open...i/riv/mistoVydani	Dordrecht
http://linked.open...vEdiceCisloSvazku	Fundamental Biomedical Technologies, 7
http://linked.open...i/riv/nazevZdroje	Intracellular Delivery II: Fundamentals and Applications
http://linked.open...in/vavai/riv/obor	EI
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...v/pocetStranKnihy	479 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...iv/tvurceVysledku	Cígler, Petr Havlík, Jan Řehoř, Ivan Raabová, Helena Muchová, Eva Šlegerová, Jitka
number of pages	39 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/978-94-017-8896-0_18
http://purl.org/ne...btex#hasPublisher	Springer-Verlag
https://schema.org/isbn	978-94-017-8895-3

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