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Description
  • Conformational preferences of the pyrrolidine ring in nucleotide analogs 7-14 were investigated by means of NMR and molecular modeling. The effect of the relative configuration of hydroxy and nucleobase substituents as well as the effect of the alkylation or acylation of the pyrrolidine nitrogen atom on the conformation of the pyrrolidine ring were studied. The results of a conformational analysis show that the alkylation/acylation can be effectively used for tuning the pyrrolidine conformation over the whole pseudorotation cycle.
  • Conformational preferences of the pyrrolidine ring in nucleotide analogs 7-14 were investigated by means of NMR and molecular modeling. The effect of the relative configuration of hydroxy and nucleobase substituents as well as the effect of the alkylation or acylation of the pyrrolidine nitrogen atom on the conformation of the pyrrolidine ring were studied. The results of a conformational analysis show that the alkylation/acylation can be effectively used for tuning the pyrrolidine conformation over the whole pseudorotation cycle. (en)
Title
  • Pyrrolidine nucleotide analogs with a tunable conformation
  • Pyrrolidine nucleotide analogs with a tunable conformation (en)
skos:prefLabel
  • Pyrrolidine nucleotide analogs with a tunable conformation
  • Pyrrolidine nucleotide analogs with a tunable conformation (en)
skos:notation
  • RIV/61388963:_____/14:00431792!RIV15-GA0-61388963
http://linked.open...avai/riv/aktivita
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  • I, P(GA13-24880S)
http://linked.open...iv/cisloPeriodika
  • Aug 22
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  • 40964
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  • RIV/61388963:_____/14:00431792
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  • conformation; NMR; nucleic acids; nucleotide analog; phosphonic acid; pseudorotation; pyrrolidine (en)
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  • DE - Spolková republika Německo
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  • [BDD6FD56375E]
http://linked.open...i/riv/nazevZdroje
  • Beilstein Journal of Organic Chemistry
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  • 10
http://linked.open...iv/tvurceVysledku
  • Pohl, Radek
  • Rejman, Dominik
  • Poštová Slavětínská, Lenka
http://linked.open...ain/vavai/riv/wos
  • 000340630700001
issn
  • 1860-5397
number of pages
http://bibframe.org/vocab/doi
  • 10.3762/bjoc.10.205
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