About: Medicinal Chemistry of Fluorinated Cyclic and Acyclic Nucleoside Phosphonates

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The fluorine atom plays an important role in medicinal chemistry because fluorine substitution has a strong impact on the physical, chemical, and biological properties of bioactive compounds. Such fluorine modifications have also been extensively studied among the pharmaceutically important class of nucleoside phosphonates, nucleotide analogues in which the phosphate group is replaced by the enzymatically and chemically stable phosphonate moiety. The fluorinated nucleoside phosphonates abound with antiviral, antiparasitic, and anticancer properties because they are able to act as inhibitors of important enzymes of nucleoside/nucleotide metabolism. In this paper, we review the biological properties of cyclic and acyclic nucleoside phosphonates modified by the attachment of one or more fluorine atoms to various parts of the molecule, namely to nucleobases, alkylphosphonate groups, cyclic or acyclic linkers, or to prodrug moieties. The fluorine atom plays an important role in medicinal chemistry because fluorine substitution has a strong impact on the physical, chemical, and biological properties of bioactive compounds. Such fluorine modifications have also been extensively studied among the pharmaceutically important class of nucleoside phosphonates, nucleotide analogues in which the phosphate group is replaced by the enzymatically and chemically stable phosphonate moiety. The fluorinated nucleoside phosphonates abound with antiviral, antiparasitic, and anticancer properties because they are able to act as inhibitors of important enzymes of nucleoside/nucleotide metabolism. In this paper, we review the biological properties of cyclic and acyclic nucleoside phosphonates modified by the attachment of one or more fluorine atoms to various parts of the molecule, namely to nucleobases, alkylphosphonate groups, cyclic or acyclic linkers, or to prodrug moieties. (en)
Title	Medicinal Chemistry of Fluorinated Cyclic and Acyclic Nucleoside Phosphonates Medicinal Chemistry of Fluorinated Cyclic and Acyclic Nucleoside Phosphonates (en)
skos:prefLabel	Medicinal Chemistry of Fluorinated Cyclic and Acyclic Nucleoside Phosphonates Medicinal Chemistry of Fluorinated Cyclic and Acyclic Nucleoside Phosphonates (en)
skos:notation	RIV/61388963:_____/13:00398512!RIV14-AV0-61388963
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Baszczyňski, Ondřej Janeba, Zlatko
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	87113
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/13:00398512
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	nucleoside phosphosphonates; fluorine; antiviral; anticancer; antiparasitic (en)
http://linked.open.../riv/klicoveSlovo	antiparasitic nucleoside phosphosphonates antiviral anticancer fluorine
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[FA626ED5B7DF]
http://linked.open...i/riv/nazevZdroje	Medicinal Research Reviews
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	33
http://linked.open...iv/tvurceVysledku	Baszczyňski, Ondřej Janeba, Zlatko
http://linked.open...ain/vavai/riv/wos	000325158000004
issn	0198-6325
number of pages	41 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/med.21296

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