About: Corylucinine, a new Alkaloid from Corydalis cava (Fumariaceae), and its Cholinesterase Activity

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About: Corylucinine, a new Alkaloid from Corydalis cava (Fumariaceae), and its Cholinesterase Activity Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A new benzyldihydroisoquinoline alkaloid (1) was isolated from the tubers of Corydalis cava and named corylucinine. Additionally, 8-trichloromethyl-7,8-dihydropalmatine (2), an isolation artifact of tetrahydropalmatine, was obtained. The structures were established by spectroscopic (including 2D NMR and optical rotation) and HR-ESI-MS methods. Both compounds were tested for human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBtiChE) inhibitory activity. In comparison with the used standards, both compounds showed only moderate inhibitory activity against HuAChE (IC50, (HuAChE) = 127.6 +/- 5.2 mu M for 1, and IC50, (HuAchE) = 82.9 +/- 3.9 mu M for 2) and none against HuBuChE. A new benzyldihydroisoquinoline alkaloid (1) was isolated from the tubers of Corydalis cava and named corylucinine. Additionally, 8-trichloromethyl-7,8-dihydropalmatine (2), an isolation artifact of tetrahydropalmatine, was obtained. The structures were established by spectroscopic (including 2D NMR and optical rotation) and HR-ESI-MS methods. Both compounds were tested for human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBtiChE) inhibitory activity. In comparison with the used standards, both compounds showed only moderate inhibitory activity against HuAChE (IC50, (HuAChE) = 127.6 +/- 5.2 mu M for 1, and IC50, (HuAchE) = 82.9 +/- 3.9 mu M for 2) and none against HuBuChE. (en)
Title	Corylucinine, a new Alkaloid from Corydalis cava (Fumariaceae), and its Cholinesterase Activity Corylucinine, a new Alkaloid from Corydalis cava (Fumariaceae), and its Cholinesterase Activity (en)
skos:prefLabel	Corylucinine, a new Alkaloid from Corydalis cava (Fumariaceae), and its Cholinesterase Activity Corylucinine, a new Alkaloid from Corydalis cava (Fumariaceae), and its Cholinesterase Activity (en)
skos:notation	RIV/61388963:_____/12:00384913!RIV13-AV0-61388963
http://linked.open...avai/riv/aktivita	I S Z
http://linked.open...avai/riv/aktivity	I, S, Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Jiroš, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	128888
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/12:00384913
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Corydalis cava; corylucinine; 8-trichloromethyl-7,8-dihydropalmatine; acetylcholinesterase; butyrylcholinesterase; Alzheimer's disease (en)
http://linked.open.../riv/klicoveSlovo	Alzheimer's disease acetylcholinesterase butyrylcholinesterase 8-dihydropalmatine 8-trichloromethyl-7 Corydalis cava corylucinine
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[5244A7A0028B]
http://linked.open...i/riv/nazevZdroje	Natural Product Communications
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Cahlíková, L. Chlebek, J. Jiroš, Pavel Kuneš, J. Macáková, K. Novák, Z. Opletal, L.
http://linked.open...ain/vavai/riv/wos	000306764200012
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	1934-578X
number of pages	2 (xsd:int)

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