About: Antimicrobial Peptide from the Eusocial Bee Halictus sexcinctus Interacting with Model Membranes

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About: Antimicrobial Peptide from the Eusocial Bee Halictus sexcinctus Interacting with Model Membranes Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Halictine-1 (Hal-1)-a linear antibacterial dodecapeptide isolated from the venom of the eusocial bee Halictus sexcinctus-has been subjected to a detailed spectroscopic study including circular dichroism, fluorescence, and vibrational spectroscopy.We investigated Hal-1 ability to adopt an amphipathic alpha-helical structure upon interaction with model lipid-based bacterial membranes (phosphatidylcholine/phosphatidylglycerol-based large unilamellar vesicles and sodium dodecylsulfate micelles) and helix inducing components (trifluoroethanol). It was found that Hal-1 responds sensitively to the composition of the membrane model and to the peptide/lipid ratio. The amphipathic nature of the helical Hal-1 seems to favour flat charged surfaces of the model lipid particles over the nondirectional interaction with trifluoroethanol. Increasing fraction of polyproline II type conformation was detected at low peptide/lipid ratios. Halictine-1 (Hal-1)-a linear antibacterial dodecapeptide isolated from the venom of the eusocial bee Halictus sexcinctus-has been subjected to a detailed spectroscopic study including circular dichroism, fluorescence, and vibrational spectroscopy.We investigated Hal-1 ability to adopt an amphipathic alpha-helical structure upon interaction with model lipid-based bacterial membranes (phosphatidylcholine/phosphatidylglycerol-based large unilamellar vesicles and sodium dodecylsulfate micelles) and helix inducing components (trifluoroethanol). It was found that Hal-1 responds sensitively to the composition of the membrane model and to the peptide/lipid ratio. The amphipathic nature of the helical Hal-1 seems to favour flat charged surfaces of the model lipid particles over the nondirectional interaction with trifluoroethanol. Increasing fraction of polyproline II type conformation was detected at low peptide/lipid ratios. (en)
Title	Antimicrobial Peptide from the Eusocial Bee Halictus sexcinctus Interacting with Model Membranes Antimicrobial Peptide from the Eusocial Bee Halictus sexcinctus Interacting with Model Membranes (en)
skos:prefLabel	Antimicrobial Peptide from the Eusocial Bee Halictus sexcinctus Interacting with Model Membranes Antimicrobial Peptide from the Eusocial Bee Halictus sexcinctus Interacting with Model Membranes (en)
skos:notation	RIV/61388963:_____/12:00378834!RIV13-AV0-61388963
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GAP208/10/0376), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	5-6
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Monincová, Lenka Čeřovský, Václav Maloň, Petr Bednárová, Lucie Pazderková, Markéta
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	122970
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/12:00378834
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	antibacterial peptides; halictine; micelle; liposome; phospholipid; circular dichroism; fluorescence; infrared spectroscopy (en)
http://linked.open.../riv/klicoveSlovo	antibacterial peptides fluorescence infrared spectroscopy phospholipid halictine micelle liposome circular dichroism
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[AF68EAB04305]
http://linked.open...i/riv/nazevZdroje	Spectroscopy
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Interaction of antibacterial peptides with the model membranes and possibility of the prediction of their biological activity
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	27
http://linked.open...iv/tvurceVysledku	Bednárová, Lucie Maloň, Petr Monincová, Lenka Čeřovský, Václav Pazderka, T. Kopecký jr., V. Kočišová, E. Pazderková, Markéta
http://linked.open...ain/vavai/riv/wos	000306505500028
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	0712-4813
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1155/2012/840956

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