About: The synthesis of phosphonic acids derived from homocysteine via transesterification reactions

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	An efficient methodology for the synthesis of S-substituted derivatives of phosphonohomocysteine has been developed. It starts from the corresponding thiols and is based on a synthetic sequence consisting of (i) the Kabachnik-Fields reaction, (ii) the transesterification of the diphenylphosphoryl moiety and (iii) the acidic deprotection of the phosphoryl and amino groups. The proposed synthetic procedures describing syntheses of phosphonohomocysteine precursors with di-tert-butylphosphoryl and tert-butyloxycarbonylamino groups could be useful for the preparation of novel S-substituted phosphonohomocysteine derivatives. An efficient methodology for the synthesis of S-substituted derivatives of phosphonohomocysteine has been developed. It starts from the corresponding thiols and is based on a synthetic sequence consisting of (i) the Kabachnik-Fields reaction, (ii) the transesterification of the diphenylphosphoryl moiety and (iii) the acidic deprotection of the phosphoryl and amino groups. The proposed synthetic procedures describing syntheses of phosphonohomocysteine precursors with di-tert-butylphosphoryl and tert-butyloxycarbonylamino groups could be useful for the preparation of novel S-substituted phosphonohomocysteine derivatives. (en)
Title	The synthesis of phosphonic acids derived from homocysteine via transesterification reactions The synthesis of phosphonic acids derived from homocysteine via transesterification reactions (en)
skos:prefLabel	The synthesis of phosphonic acids derived from homocysteine via transesterification reactions The synthesis of phosphonic acids derived from homocysteine via transesterification reactions (en)
skos:notation	RIV/61388963:_____/12:00376577!RIV13-AV0-61388963
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/09/1919), P(GAP207/10/1277), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Buděšínský, Miloš Fiedler, Pavel Jiráček, Jiří Pícha, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	172980
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/12:00376577
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	phosphonohomocysteine; aminophosphonic acids (en)
http://linked.open.../riv/klicoveSlovo	aminophosphonic acids phosphonohomocysteine
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[D357CCED357A]
http://linked.open...i/riv/nazevZdroje	ARKIVOC
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of methods for configuration determination at chiral sulfur, nitrogen or phosphorus atom using NMR spectroscopy and ab initio calculations New inhibitors for human methyltransferases BHMT and BHMT-2 to study their physiological functions
http://linked.open...UplatneniVysledku	2012
http://linked.open...iv/tvurceVysledku	Buděšínský, Miloš Fiedler, Pavel Pícha, Jan Jiráček, Jiří
http://linked.open...ain/vavai/riv/wos	000308692300008
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	1551-7004
number of pages	20 (xsd:int)

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