About: Involvement of MAP Kinases in the Cytotoxicity of Acyclic Nucleoside Phosphonates

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About: Involvement of MAP Kinases in the Cytotoxicity of Acyclic Nucleoside Phosphonates Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The role of ERK, p38, JNK and AKT kinases in PMEG-induced apoptosis was investigated in CCRF-CEM and HL-60 leukemia cells. First, MAPK mRNA and protein expression were assessed in PMEG-treated cells. MAPK activation was then measured using phospho-specific antibodies. Up-regulation of p38beta, gamma and delta mRNA were observed following PMEG treatment of CCRF-CEM cells, however, the total protein expression remained unchanged. Neither PMEG nor its analogue 9-[2-(phosphonomethoxy)ethyl]-2,6-diaminopurine (PMEDAP) induced p38 kinase phosphorylation in CCRF-CEM cells, whereas increased p38 phosphorylation was observed in HL-60 cells. The ERK, JNK or AKT pathways did not. PMEG- and PMEDAP-induced cytotoxicity is therefore partly mediated by the p38 pathway in human leukemia cells. The role of ERK, p38, JNK and AKT kinases in PMEG-induced apoptosis was investigated in CCRF-CEM and HL-60 leukemia cells. First, MAPK mRNA and protein expression were assessed in PMEG-treated cells. MAPK activation was then measured using phospho-specific antibodies. Up-regulation of p38beta, gamma and delta mRNA were observed following PMEG treatment of CCRF-CEM cells, however, the total protein expression remained unchanged. Neither PMEG nor its analogue 9-[2-(phosphonomethoxy)ethyl]-2,6-diaminopurine (PMEDAP) induced p38 kinase phosphorylation in CCRF-CEM cells, whereas increased p38 phosphorylation was observed in HL-60 cells. The ERK, JNK or AKT pathways did not. PMEG- and PMEDAP-induced cytotoxicity is therefore partly mediated by the p38 pathway in human leukemia cells. (en)
Title	Involvement of MAP Kinases in the Cytotoxicity of Acyclic Nucleoside Phosphonates Involvement of MAP Kinases in the Cytotoxicity of Acyclic Nucleoside Phosphonates (en)
skos:prefLabel	Involvement of MAP Kinases in the Cytotoxicity of Acyclic Nucleoside Phosphonates Involvement of MAP Kinases in the Cytotoxicity of Acyclic Nucleoside Phosphonates (en)
skos:notation	RIV/61388963:_____/12:00376351!RIV13-AV0-61388963
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0508), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Votruba, Ivan Holý, Antonín Mertlíková-Kaiserová, Helena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	142970
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/12:00376351
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	MAPK; p38; apoptosis; nucleotide analogs (en)
http://linked.open.../riv/klicoveSlovo	p38 MAPK nucleotide analogs apoptosis
http://linked.open...odStatuVydavatele	GR - Řecká republika
http://linked.open...ontrolniKodProRIV	[528CA5445B0D]
http://linked.open...i/riv/nazevZdroje	Anticancer Research
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	New Antivirals and Antineoplastics
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	32
http://linked.open...iv/tvurceVysledku	Holý, Antonín Mertlíková-Kaiserová, Helena Votruba, Ivan Nejedlá, M.
http://linked.open...ain/vavai/riv/wos	000299985800013
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	0250-7005
number of pages	6 (xsd:int)

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