About: Determination of the antioxidative activity of substituted 5-aminopyrimidines

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aminopyrimidine structural motif can be found in diverse biologically active compounds. This study aimed to describe the antioxidant activity of a series of di- and tri-substituted 5-aminopyrimidines using in vitro (TEAC, LPO) and cell-based assays. 2,4,6-trisubstituted 5-aminopyrimidines displayed the highest activity in the TEAC and LPO assays whereas compounds with protected 5-aminogroup were active in the cellular assay. This is most likely because of their better membrane permeability and intracellular metabolic activation. In summary, we have identified the antioxidant activity of a series of substituted 5-aminopyrimidines and their potential prodrugs which may have implications in the treatment of oxidative stress-related diseases. The aminopyrimidine structural motif can be found in diverse biologically active compounds. This study aimed to describe the antioxidant activity of a series of di- and tri-substituted 5-aminopyrimidines using in vitro (TEAC, LPO) and cell-based assays. 2,4,6-trisubstituted 5-aminopyrimidines displayed the highest activity in the TEAC and LPO assays whereas compounds with protected 5-aminogroup were active in the cellular assay. This is most likely because of their better membrane permeability and intracellular metabolic activation. In summary, we have identified the antioxidant activity of a series of substituted 5-aminopyrimidines and their potential prodrugs which may have implications in the treatment of oxidative stress-related diseases. (en)
Title	Determination of the antioxidative activity of substituted 5-aminopyrimidines Determination of the antioxidative activity of substituted 5-aminopyrimidines (en)
skos:prefLabel	Determination of the antioxidative activity of substituted 5-aminopyrimidines Determination of the antioxidative activity of substituted 5-aminopyrimidines (en)
skos:notation	RIV/61388963:_____/12:00376349!RIV13-AV0-61388963
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0508), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Jansa, Petr Holý, Antonín Dračínský, Martin Mertlíková-Kaiserová, Helena Procházková, Eliška
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	130643
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/12:00376349
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	5-aminopyrimidines; TEAC; lipid peroxidation; HepG2 (en)
http://linked.open.../riv/klicoveSlovo	TEAC 5-aminopyrimidines HepG2 lipid peroxidation
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[7D7ADE7A143E]
http://linked.open...i/riv/nazevZdroje	Free Radical Research
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	New Antivirals and Antineoplastics
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	46
http://linked.open...iv/tvurceVysledku	Dračínský, Martin Holý, Antonín Jansa, Petr Mertlíková-Kaiserová, Helena Procházková, Eliška
http://linked.open...ain/vavai/riv/wos	000297814900008
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	1071-5762
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.3109/10715762.2011.638292

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