About: 4'-Alkoxy oligodeoxynucleotides: a novel class of RNA mimics

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	4´-Alkoxy-oligothymidylates were prepared as model compounds to study the influence of a C4´-alkoxy group on hybridisation. The phosphodiester homooligomers (15 units long) containing either a 4´-methoxy or 4´-(2-methoxyethoxy) group were found to display increased hybridisation with both dA15 and rA15 complementary counterparts compared to the natural oligothymidylate. In addition, their hybridisation behaviour was found to be similar to that of the regioisomeric 2´-O-methyl-oligothymidylate. The 4´-alkoxy modified nucleotides seem to be promising compounds for assembly of chimeric oligonucleotides with tunable properties. 4´-Alkoxy-oligothymidylates were prepared as model compounds to study the influence of a C4´-alkoxy group on hybridisation. The phosphodiester homooligomers (15 units long) containing either a 4´-methoxy or 4´-(2-methoxyethoxy) group were found to display increased hybridisation with both dA15 and rA15 complementary counterparts compared to the natural oligothymidylate. In addition, their hybridisation behaviour was found to be similar to that of the regioisomeric 2´-O-methyl-oligothymidylate. The 4´-alkoxy modified nucleotides seem to be promising compounds for assembly of chimeric oligonucleotides with tunable properties. (en)
Title	4'-Alkoxy oligodeoxynucleotides: a novel class of RNA mimics 4'-Alkoxy oligodeoxynucleotides: a novel class of RNA mimics (en)
skos:prefLabel	4'-Alkoxy oligodeoxynucleotides: a novel class of RNA mimics 4'-Alkoxy oligodeoxynucleotides: a novel class of RNA mimics (en)
skos:notation	RIV/61388963:_____/11:00369807!RIV12-AV0-61388963
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA202/09/0193), P(KAN200520801), P(LC06061), Z(AV0Z40550506), Z(MSM0021620835)
http://linked.open...iv/cisloPeriodika	24
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Rosenberg, Ivan Buděšínský, Miloš Pohl, Radek Rejman, Dominik Točík, Zdeněk Páv, Ondřej Liboska, Radek Snášel, Jan Novák, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	244148
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/11:00369807
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	4'-alkoxy oligothymidylates; modified oligonucleotides; oligonucleotide hybridisation; RNA mimics (en)
http://linked.open.../riv/klicoveSlovo	4'-alkoxy oligothymidylates RNA mimics modified oligonucleotides oligonucleotide hybridisation
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[0EF7D78BBBE1]
http://linked.open...i/riv/nazevZdroje	Organic & Biomolecular Chemistry
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Cell Invasiveness in Embryonic Development and Tumour Metastases Formation and dynamics of nucleic acid motifs involved in regulation of gene expression Targeted expression and transport of bioactive molecules
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Buděšínský, Miloš Novák, Pavel Pohl, Radek Rosenberg, Ivan Rejman, Dominik Barvík, I. Páv, Ondřej Točík, Zdeněk Liboska, Radek Snášel, Jan
http://linked.open...ain/vavai/riv/wos	000297354100008
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství Fyzika molekulárních, makromolekulárních a biologických systémů
issn	1477-0520
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1039/c1ob06148h

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