About: Isolation and Cholinesterase Activity of Amaryllidaceae Alkaloids from Nerine bowdenii     Goto   Sponge   NotDistinct   Permalink

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  • Amaryllidaceae species are known as ornamental plants. Some contain galanthamine, an acetylcholinesterase inhibitor. The chemical composition of the alkaloid extract of bulbs of Nerine bowdenii Watson has been analyzed by means of GC/MS. Twenty-two compounds were detected and nineteen of them identified, one of which was belladine. The alkaloid extract showed promising cholinesterase inhibitory activities against human blood acetylcholinesterase (HuAChE; IC50= 87.9.+-.3.5 .mu.g/mL) and human plasma butyrylcholinesterase (HuBuChE; IC50 = 14.8.+-.1.1 .mu.g/mL). Belladine inhibited HuAChE and HuBuChE in a dose-dependent manner with IC50 values of 781.+-.12.5 .mu.M and 284.84.2 .mu.M, respectively.
  • Amaryllidaceae species are known as ornamental plants. Some contain galanthamine, an acetylcholinesterase inhibitor. The chemical composition of the alkaloid extract of bulbs of Nerine bowdenii Watson has been analyzed by means of GC/MS. Twenty-two compounds were detected and nineteen of them identified, one of which was belladine. The alkaloid extract showed promising cholinesterase inhibitory activities against human blood acetylcholinesterase (HuAChE; IC50= 87.9.+-.3.5 .mu.g/mL) and human plasma butyrylcholinesterase (HuBuChE; IC50 = 14.8.+-.1.1 .mu.g/mL). Belladine inhibited HuAChE and HuBuChE in a dose-dependent manner with IC50 values of 781.+-.12.5 .mu.M and 284.84.2 .mu.M, respectively. (en)
Title
  • Isolation and Cholinesterase Activity of Amaryllidaceae Alkaloids from Nerine bowdenii
  • Isolation and Cholinesterase Activity of Amaryllidaceae Alkaloids from Nerine bowdenii (en)
skos:prefLabel
  • Isolation and Cholinesterase Activity of Amaryllidaceae Alkaloids from Nerine bowdenii
  • Isolation and Cholinesterase Activity of Amaryllidaceae Alkaloids from Nerine bowdenii (en)
skos:notation
  • RIV/61388963:_____/11:00369375!RIV12-AV0-61388963
http://linked.open...avai/riv/aktivita
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  • S, Z(AV0Z40550506), Z(MSM0021620822)
http://linked.open...iv/cisloPeriodika
  • 12
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  • 205912
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  • RIV/61388963:_____/11:00369375
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  • Nerine bowdenii; GC/MS; belladine; acetylcholinesterase (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
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  • [DED817E93EAC]
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  • Natural Product Communications
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  • 6
http://linked.open...iv/tvurceVysledku
  • Cahlíková, L.
  • Kuneš, J.
  • Macáková, K.
  • Opletal, L.
  • Valterová, Irena
  • Zavadil, S.
  • Hošťálková, A.
  • Kulhánková, A.
http://linked.open...ain/vavai/riv/wos
  • 000298445300010
http://linked.open...n/vavai/riv/zamer
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  • 1934-578X
number of pages
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