About: Lucifensin, a Novel Insect Defensin of Medicinal Maggots: Synthesis and Structural Study     Goto   Sponge   NotDistinct   Permalink

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Description
  • Lucifensin, a novel insect defensin of medicinal maggots identified recently in our laboratory, is 40 amino acid residues and three intramolecular bridges peptide. Oxidative folding of linear lucifensin precursor prepared by solid phase peptide synthesis resulted in a peptide with a pattern of disulfide bridges identical to that of native lucifensin. Synthetic lucifensin was active against Gram-positive bacteria and was not hemolytic. The presence of disulfide bridges and the N-terminal part of its molecule for the structure and antimicrobial activity is essential.
  • Lucifensin, a novel insect defensin of medicinal maggots identified recently in our laboratory, is 40 amino acid residues and three intramolecular bridges peptide. Oxidative folding of linear lucifensin precursor prepared by solid phase peptide synthesis resulted in a peptide with a pattern of disulfide bridges identical to that of native lucifensin. Synthetic lucifensin was active against Gram-positive bacteria and was not hemolytic. The presence of disulfide bridges and the N-terminal part of its molecule for the structure and antimicrobial activity is essential. (en)
Title
  • Lucifensin, a Novel Insect Defensin of Medicinal Maggots: Synthesis and Structural Study
  • Lucifensin, a Novel Insect Defensin of Medicinal Maggots: Synthesis and Structural Study (en)
skos:prefLabel
  • Lucifensin, a Novel Insect Defensin of Medicinal Maggots: Synthesis and Structural Study
  • Lucifensin, a Novel Insect Defensin of Medicinal Maggots: Synthesis and Structural Study (en)
skos:notation
  • RIV/61388963:_____/11:00364530!RIV12-AV0-61388963
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA203/08/0536), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika
  • 9
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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  • 210061
http://linked.open...ai/riv/idVysledku
  • RIV/61388963:_____/11:00364530
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • antimicrobial peptide; disulfide bridge; lucifensin; solid phase synthesis (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV
  • [1C7660EA968C]
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  • Chembiochem
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http://linked.open...v/svazekPeriodika
  • 12
http://linked.open...iv/tvurceVysledku
  • Bednárová, Lucie
  • Fučík, Vladimír
  • Maloň, Petr
  • Monincová, Lenka
  • Slaninová, Jiřina
  • Čeřovský, Václav
  • Štokrová, Jitka
http://linked.open...ain/vavai/riv/wos
  • 000292096100011
http://linked.open...n/vavai/riv/zamer
issn
  • 1439-4227
number of pages
http://bibframe.org/vocab/doi
  • 10.1002/cbic.201100066
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