About: Modular synthesis of 1-.alpha.- and 1-.beta.-(indol-2-yl)-2´-deoxyribose C-nucleosides

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About: Modular synthesis of 1-.alpha.- and 1-.beta.-(indol-2-yl)-2´-deoxyribose C-nucleosides Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A simple two-step method for the selective preparation of anomerically pure 1 alpha- and 1 beta-(indol-2-yl)deoxyribose derivatives was developed. The synthesis was based on the Sonogashira reaction of 1 alpha- and 1 beta-ethynyldeoxyribose and 2-haloanilines followed by a Pd-complex catalyzed cyclization to the corresponding indolyldeoxyribosides. A simple two-step method for the selective preparation of anomerically pure 1 alpha- and 1 beta-(indol-2-yl)deoxyribose derivatives was developed. The synthesis was based on the Sonogashira reaction of 1 alpha- and 1 beta-ethynyldeoxyribose and 2-haloanilines followed by a Pd-complex catalyzed cyclization to the corresponding indolyldeoxyribosides. (en)
Title	Modular synthesis of 1-.alpha.- and 1-.beta.-(indol-2-yl)-2´-deoxyribose C-nucleosides Modular synthesis of 1-.alpha.- and 1-.beta.-(indol-2-yl)-2´-deoxyribose C-nucleosides (en)
skos:prefLabel	Modular synthesis of 1-.alpha.- and 1-.beta.-(indol-2-yl)-2´-deoxyribose C-nucleosides Modular synthesis of 1-.alpha.- and 1-.beta.-(indol-2-yl)-2´-deoxyribose C-nucleosides (en)
skos:notation	RIV/61388963:_____/11:00364260!RIV12-AV0-61388963
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0508), P(IAA400550902), Z(AV0Z40550506), Z(MSM0021620857)
http://linked.open...iv/cisloPeriodika	17
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Kotora, Martin Hocek, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	213403
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/11:00364260
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	efficient synthesis; indole derivatives; aromatic stacking; DNA; cyclization (en)
http://linked.open.../riv/klicoveSlovo	aromatic stacking efficient synthesis indole derivatives DNA cyclization
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[2DD4C8C2B280]
http://linked.open...i/riv/nazevZdroje	Organic & Biomolecular Chemistry
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	New Antivirals and Antineoplastics Development of modular syntheses of new C-nucleosides for studying DNA polymerase specificity and for the extension of the genetic alphabet
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Hocek, Michal Kotora, Martin Nečas, D. Hidasová, D.
http://linked.open...ain/vavai/riv/wos	000293756800005
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství Nové molekulární systémy pro pokročilé aplikace prospěšné pro zdraví a šetrné k životnímu prostředí
issn	1477-0520
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1039/c1ob05844d

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