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  • Plasmodium falciparum and Plasmodium vivax are the predominant causative agents of malaria. One metabolic pathway crucial for the survival and replication and survival of the parasite is the synthesis of the purine nucleoside monophosphates. The focus of this review is on the identification and characterization of inhibitors of the key enzyme in this pathway - 6-oxopurine phosphoribosyltransferase. The acyclic nucleoside phosphonates (ANPs) appear to be excellent candidates that can be selective compared to the human enzyme.
  • Plasmodium falciparum and Plasmodium vivax are the predominant causative agents of malaria. One metabolic pathway crucial for the survival and replication and survival of the parasite is the synthesis of the purine nucleoside monophosphates. The focus of this review is on the identification and characterization of inhibitors of the key enzyme in this pathway - 6-oxopurine phosphoribosyltransferase. The acyclic nucleoside phosphonates (ANPs) appear to be excellent candidates that can be selective compared to the human enzyme. (en)
Title
  • 6-Oxopurine Phosphoribosyltransferase: A Target for the Development of Antimalarial Drugs
  • 6-Oxopurine Phosphoribosyltransferase: A Target for the Development of Antimalarial Drugs (en)
skos:prefLabel
  • 6-Oxopurine Phosphoribosyltransferase: A Target for the Development of Antimalarial Drugs
  • 6-Oxopurine Phosphoribosyltransferase: A Target for the Development of Antimalarial Drugs (en)
skos:notation
  • RIV/61388963:_____/11:00363423!RIV12-AV0-61388963
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1M0508), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika
  • 16
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  • 244240
http://linked.open...ai/riv/idVysledku
  • RIV/61388963:_____/11:00363423
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  • Malaria; acyclic nucleoside phosphonates; hypoxanthine; guanine phosphoribosyl transferase (en)
http://linked.open.../riv/klicoveSlovo
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  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [8985CCABAED2]
http://linked.open...i/riv/nazevZdroje
  • Current Topics in Medicinal Chemistry
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  • 11
http://linked.open...iv/tvurceVysledku
  • Holý, Antonín
  • Hocková, Dana
  • Guddat, L. W.
  • Keough, D. T.
  • Naesens, L.
  • de Jersey, J.
http://linked.open...ain/vavai/riv/wos
  • 000293858200008
http://linked.open...n/vavai/riv/zamer
issn
  • 1568-0266
number of pages
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