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  • 1-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine (HPMP-5-azaC), its cyclic form and a series of ester prodrugs were prepared as a new type of antiviral agents active against all species of DNA viruses in vitro and in vivo. HPMP-5-azaC showed a 2- to 16-fold higher antiviral selectivity index compared to cidofovir.
  • 1-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine (HPMP-5-azaC), its cyclic form and a series of ester prodrugs were prepared as a new type of antiviral agents active against all species of DNA viruses in vitro and in vivo. HPMP-5-azaC showed a 2- to 16-fold higher antiviral selectivity index compared to cidofovir. (en)
Title
  • Azacytosine Derivatives Useful as Antiviral Agents
  • Azacytosine Derivatives Useful as Antiviral Agents (en)
skos:prefLabel
  • Azacytosine Derivatives Useful as Antiviral Agents
  • Azacytosine Derivatives Useful as Antiviral Agents (en)
skos:notation
  • RIV/61388963:_____/10:00356428!RIV11-MSM-61388963
http://linked.open...avai/riv/aktivita
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  • P(1M0508), Z(AV0Z40550506)
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  • EP1966226
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  • 248317
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  • RIV/61388963:_____/10:00356428
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  • 5-azacytosine; triazine; antivirals; acyclic nucleoside phosphonates (en)
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  • [51B46324C38A]
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  • Munich
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  • European Patent Office http://v3.espacenet.com/publicationDetails/originalDocument?FT=D&date=20101110&DB=EPODOC&locale=en_EP&CC=EP&NR=1966226B1&KC=B1
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  • Andrei, G.
  • Holý, Antonín
  • Krečmerová, Marcela
  • Neyts, J.
  • Snoeck, R.
  • De Clercq, E.
  • Naesens, L.
  • Pískala, Alois
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  • Ústav organické chemie a biochemie AV ČR, v. v. i. - K.U. Leuven Research and Development, Leuven, BE
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