About: Inhibition of human purine nucleoside phosphorylase by tenofovir phosphate congeners

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About: Inhibition of human purine nucleoside phosphorylase by tenofovir phosphate congeners Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The structure-activity study on the phosphates of phosphonomethoxypropyl derivatives of purine bases interacting with human purine nucleoside phosphorylase has shown that the most efficient inhibitors of the enzyme are (R)- and (S)-PMPGp with Ki - 1.9 x 10-8 mol.l-1and/or 2.2 x 10-8 mol.l-1. These results were confirmed by docking studies. The structure-activity study on the phosphates of phosphonomethoxypropyl derivatives of purine bases interacting with human purine nucleoside phosphorylase has shown that the most efficient inhibitors of the enzyme are (R)- and (S)-PMPGp with Ki - 1.9 x 10-8 mol.l-1and/or 2.2 x 10-8 mol.l-1. These results were confirmed by docking studies. (en)
Title	Inhibition of human purine nucleoside phosphorylase by tenofovir phosphate congeners Inhibition of human purine nucleoside phosphorylase by tenofovir phosphate congeners (en)
skos:prefLabel	Inhibition of human purine nucleoside phosphorylase by tenofovir phosphate congeners Inhibition of human purine nucleoside phosphorylase by tenofovir phosphate congeners (en)
skos:notation	RIV/61388963:_____/10:00351497!RIV11-MSM-61388963
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0508), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Horská, Květoslava Trýznová, Jana Votruba, Ivan Břehová, Petra Holý, Antonín Fanfrlík, Jindřich Přenosil, Ondřej Tloušťová, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	264002
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/10:00351497
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	purine nucleoside phosphorylase; phosphates of acyclic nucleoside; phosphonates; tenofovir phosphate congeners (en)
http://linked.open.../riv/klicoveSlovo	phosphates of acyclic nucleoside purine nucleoside phosphorylase tenofovir phosphate congeners phosphonates
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[8A2EB3C8EB81]
http://linked.open...i/riv/nazevZdroje	Collection of Czechoslovak Chemical Communications
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	New Antivirals and Antineoplastics
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	75
http://linked.open...iv/tvurceVysledku	Holý, Antonín Votruba, Ivan Břehová, Petra Fanfrlík, Jindřich Přenosil, Ondřej Tloušťová, Eva Horská, Květoslava Trýznová, Jana
http://linked.open...ain/vavai/riv/wos	000285770100003
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	0010-0765
number of pages	9 (xsd:int)

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