About: Melectin MAPs: the influence of dendrimerization on antimicrobial and hemolytic activity

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About: Melectin MAPs: the influence of dendrimerization on antimicrobial and hemolytic activity Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The influence of dimerization and tetramerization of peptide melectin (GFLSILKKVLPKVMAHMK-NH2) on its antimicrobial and hemolytic activities, as well as the role of Met in positions 14 and 17 of its peptide chain, was studied. 23 new analogues were synthesized. Dimerization and tetramerization increased the undesirable hemolytic activity. Introduction of the isosteric amino acid Nle into positions 14 or 17 or both led to only slight increase of hemolytic activity under preservation of high antimicrobial activities. Substitution of Leu for Val in position 6 led to the decrease of hemolytic activity. The influence of dimerization and tetramerization of peptide melectin (GFLSILKKVLPKVMAHMK-NH2) on its antimicrobial and hemolytic activities, as well as the role of Met in positions 14 and 17 of its peptide chain, was studied. 23 new analogues were synthesized. Dimerization and tetramerization increased the undesirable hemolytic activity. Introduction of the isosteric amino acid Nle into positions 14 or 17 or both led to only slight increase of hemolytic activity under preservation of high antimicrobial activities. Substitution of Leu for Val in position 6 led to the decrease of hemolytic activity. (en)
Title	Melectin MAPs: the influence of dendrimerization on antimicrobial and hemolytic activity Melectin MAPs: the influence of dendrimerization on antimicrobial and hemolytic activity (en)
skos:prefLabel	Melectin MAPs: the influence of dendrimerization on antimicrobial and hemolytic activity Melectin MAPs: the influence of dendrimerization on antimicrobial and hemolytic activity (en)
skos:notation	RIV/61388963:_____/10:00351324!RIV11-GA0-61388963
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/03/1362), P(GA203/09/1919), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Slaninová, Jiřina Fučík, Vladimír Borovičková, Lenka Čeřovský, Václav Buděšínský, Miloš Šafařík, Martin Bednárová, Lucie Niederhafner, Petr Ježek, Jan Ehala, Sille
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	270309
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/10:00351324
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	melectin; antibacterial peptides; dendrimers; hemolytic activity (en)
http://linked.open.../riv/klicoveSlovo	antibacterial peptides melectin dendrimers hemolytic activity
http://linked.open...odStatuVydavatele	AT - Rakouská republika
http://linked.open...ontrolniKodProRIV	[FBE6C688CB1C]
http://linked.open...i/riv/nazevZdroje	Amino Acids
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	10 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Synthesis and characterization of synthetic antigens Development of methods for configuration determination at chiral sulfur, nitrogen or phosphorus atom using NMR spectroscopy and ab initio calculations
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	39
http://linked.open...iv/tvurceVysledku	Bednárová, Lucie Borovičková, Lenka Buděšínský, Miloš Ehala, Sille Fučík, Vladimír Ježek, Jan Slaninová, Jiřina Čeřovský, Václav Šafařík, Martin Niederhafner, Petr
http://linked.open...ain/vavai/riv/wos	000283502900044
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	0939-4451
number of pages	9 (xsd:int)

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