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rdf:type
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Description
| - The following structurally diverse types of esters of (S)-HPMPDAP and its cyclic form were prepared: alkoxyalkyl, pivaloyloxymethyl (POM), 2,2,2-(trifluoro)ethyl, butylsalicylyl, and ester bound peptidomimetics. The activity was evaluated not only against vaccinia virus but also against different herpesviruses. The most potent and active prodrugs against vaccinia virus were the alkoxyalkyl ester derivatives followed by POM esters.
- The following structurally diverse types of esters of (S)-HPMPDAP and its cyclic form were prepared: alkoxyalkyl, pivaloyloxymethyl (POM), 2,2,2-(trifluoro)ethyl, butylsalicylyl, and ester bound peptidomimetics. The activity was evaluated not only against vaccinia virus but also against different herpesviruses. The most potent and active prodrugs against vaccinia virus were the alkoxyalkyl ester derivatives followed by POM esters. (en)
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Title
| - Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents
- Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents (en)
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skos:prefLabel
| - Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents
- Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents (en)
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skos:notation
| - RIV/61388963:_____/10:00350272!RIV11-MSM-61388963
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(1M0508), P(ME10040), Z(AV0Z40550506)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61388963:_____/10:00350272
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - phosphonates; prodrugs; poxvirus; herpes virus; bioterrorism (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Journal of Medicinal Chemistry
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Andrei, G.
- Balzarini, J.
- Dračínský, Martin
- Holý, Antonín
- Krečmerová, Marcela
- Neyts, J.
- Pohl, Radek
- Snoeck, R.
- Tichý, Tomáš
- Břehová, Petra
- De Clercq, E.
- Masojídková, Milena
- Naesens, L.
- Pomeisl, Karel
- Cihlař, T.
- Hui, H.
- Laflamme, G.
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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