About: The Noncanonical Gag Domains p8 and n Are Critical for Assembly and Release of Mouse Mammary Tumor Virus     Goto   Sponge   NotDistinct   Permalink

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Description
  • The mouse mammary tumor virus (MMTV) Gag contains the unique domains pp21, p3, p8 and n. We investigated the contribution of these domains to particle assembly and found that the region spanning the p8 and n domains is critical for shape determination and assembly. Deletion of pp21 and p3 reduced the number of released particles, but deletion of the n domain resulted in frequent formation of aberrant particles, while deletion of p8 severely impaired assembly. Further investigation of the p8 revealed that both the basic and the proline-rich motifs within p8 contribute to MMTV assembly.
  • The mouse mammary tumor virus (MMTV) Gag contains the unique domains pp21, p3, p8 and n. We investigated the contribution of these domains to particle assembly and found that the region spanning the p8 and n domains is critical for shape determination and assembly. Deletion of pp21 and p3 reduced the number of released particles, but deletion of the n domain resulted in frequent formation of aberrant particles, while deletion of p8 severely impaired assembly. Further investigation of the p8 revealed that both the basic and the proline-rich motifs within p8 contribute to MMTV assembly. (en)
Title
  • The Noncanonical Gag Domains p8 and n Are Critical for Assembly and Release of Mouse Mammary Tumor Virus
  • The Noncanonical Gag Domains p8 and n Are Critical for Assembly and Release of Mouse Mammary Tumor Virus (en)
skos:prefLabel
  • The Noncanonical Gag Domains p8 and n Are Critical for Assembly and Release of Mouse Mammary Tumor Virus
  • The Noncanonical Gag Domains p8 and n Are Critical for Assembly and Release of Mouse Mammary Tumor Virus (en)
skos:notation
  • RIV/61388963:_____/10:00349410!RIV11-MSM-61388963
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1M0508), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika
  • 21
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 274978
http://linked.open...ai/riv/idVysledku
  • RIV/61388963:_____/10:00349410
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • betaretrovirus; Gag; assembly (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [4B14541A256D]
http://linked.open...i/riv/nazevZdroje
  • Journal of Virology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 84
http://linked.open...iv/tvurceVysledku
  • Pichová, Iva
  • Štokrová, Jitka
  • Hadravová, Romana
  • Zábranský, Aleš
  • Hoboth, Peter
  • Sakalian, M.
http://linked.open...ain/vavai/riv/wos
  • 000282643400059
http://linked.open...n/vavai/riv/zamer
issn
  • 0022-538X
number of pages
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