About: Role of Caspases and CD95/Fas in the Apoptotic Effects of a Nucleotide Analog PMEG in CCRF-CEM Cells

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About: Role of Caspases and CD95/Fas in the Apoptotic Effects of a Nucleotide Analog PMEG in CCRF-CEM Cells Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	9-[2-(phosphonomethoxy)ethyl] guanine (PMEG) is a guanine acyclic nucleotide analog whose prodrugs are being investigated for chemotherapy of lymphomas. The objective of this study was to determine the requirements for caspase and CD95/Fas activation in PMEG-induced apoptosis and the influence of PMEG on cell cycle regulatory proteins in CCRF-CEM cells. As for cell cycle regulation, cyclin E1 was found to be up-regulated following PMEG treatment. Although an increase of caspase 3, 8 and 9 proteolytic activity was observed, neither pretreatment of the cells with cell-permeable caspase inhibitors nor blocking the death receptor with anti-Fas antibody did prevent apoptosis induced by PMEG. It was concluded that PMEG-induced apoptosis is caspase- and CD95/Fas-independent. 9-[2-(phosphonomethoxy)ethyl] guanine (PMEG) is a guanine acyclic nucleotide analog whose prodrugs are being investigated for chemotherapy of lymphomas. The objective of this study was to determine the requirements for caspase and CD95/Fas activation in PMEG-induced apoptosis and the influence of PMEG on cell cycle regulatory proteins in CCRF-CEM cells. As for cell cycle regulation, cyclin E1 was found to be up-regulated following PMEG treatment. Although an increase of caspase 3, 8 and 9 proteolytic activity was observed, neither pretreatment of the cells with cell-permeable caspase inhibitors nor blocking the death receptor with anti-Fas antibody did prevent apoptosis induced by PMEG. It was concluded that PMEG-induced apoptosis is caspase- and CD95/Fas-independent. (en)
Title	Role of Caspases and CD95/Fas in the Apoptotic Effects of a Nucleotide Analog PMEG in CCRF-CEM Cells Role of Caspases and CD95/Fas in the Apoptotic Effects of a Nucleotide Analog PMEG in CCRF-CEM Cells (en)
skos:prefLabel	Role of Caspases and CD95/Fas in the Apoptotic Effects of a Nucleotide Analog PMEG in CCRF-CEM Cells Role of Caspases and CD95/Fas in the Apoptotic Effects of a Nucleotide Analog PMEG in CCRF-CEM Cells (en)
skos:notation	RIV/61388963:_____/10:00346305!RIV11-MSM-61388963
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0508), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Votruba, Ivan Hájek, Miroslav Holý, Antonín Mertlíková-Kaiserová, Helena Matoušová, Marika
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	285683
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/10:00346305
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	acyclic nucleoside phosphonate; programmed cell death; CCRF-CEM cells; cell cycle (en)
http://linked.open.../riv/klicoveSlovo	programmed cell death CCRF-CEM cells cell cycle acyclic nucleoside phosphonate
http://linked.open...odStatuVydavatele	GR - Řecká republika
http://linked.open...ontrolniKodProRIV	[181DCABFC0B6]
http://linked.open...i/riv/nazevZdroje	Anticancer Research
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	New Antivirals and Antineoplastics
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	30
http://linked.open...iv/tvurceVysledku	Holý, Antonín Mertlíková-Kaiserová, Helena Votruba, Ivan Hájek, Miroslav Matoušová, Marika
http://linked.open...ain/vavai/riv/wos	000280796400043
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	0250-7005
number of pages	8 (xsd:int)

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