About: The preparation of 3-H-labeled Acyclic Nucleoside Phosphonates and Study of their Stability

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	9-(2-Phosphonomethoxyethyl)-2,6-diamino-[8-3H]purine, 9-(2-phosphonomethoxyethyl)- [8-3H]guanine and (R)- 9-(2-phosphonomethoxypropyl)-[8-3H]adenine with specific activities of 10.9 Ci/mmol, 7.9 Ci/mmol and 16 Ci/mmol, respectively, were prepared by a catalytic dehalogenation of the corresponding 8-bromo derivatives. The rate of the exchange of the tritium label on C-8 of the purine ring in title compounds with the hydrogen of water under physiological pH at 20 °C was studied using 3H NMR. 9-(2-Phosphonomethoxyethyl)-2,6-diamino-[8-3H]purine, 9-(2-phosphonomethoxyethyl)- [8-3H]guanine and (R)- 9-(2-phosphonomethoxypropyl)-[8-3H]adenine with specific activities of 10.9 Ci/mmol, 7.9 Ci/mmol and 16 Ci/mmol, respectively, were prepared by a catalytic dehalogenation of the corresponding 8-bromo derivatives. The rate of the exchange of the tritium label on C-8 of the purine ring in title compounds with the hydrogen of water under physiological pH at 20 °C was studied using 3H NMR. (en)
Title	The preparation of 3-H-labeled Acyclic Nucleoside Phosphonates and Study of their Stability The preparation of 3-H-labeled Acyclic Nucleoside Phosphonates and Study of their Stability (en)
skos:prefLabel	The preparation of 3-H-labeled Acyclic Nucleoside Phosphonates and Study of their Stability The preparation of 3-H-labeled Acyclic Nucleoside Phosphonates and Study of their Stability (en)
skos:notation	RIV/61388963:_____/10:00346290!RIV11-MSM-61388963
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0508), P(IAA400550801), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Břehová, Petra Holý, Antonín Elbert, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	281407
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/10:00346290
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	tritium; 3-H NMR; acyclic nucleotide analogues (en)
http://linked.open.../riv/klicoveSlovo	tritium 3-H NMR acyclic nucleotide analogues
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[6AD1A1BD1E5B]
http://linked.open...i/riv/nazevZdroje	Collection of Czechoslovak Chemical Communications
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Synthesis of tritium labelled brassinosteroids and their application in the studies of their mechanism of action on molecular level. New Antivirals and Antineoplastics
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	75
http://linked.open...iv/tvurceVysledku	Elbert, Tomáš Holý, Antonín Břehová, Petra
http://linked.open...ain/vavai/riv/wos	000280518100004
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	0010-0765
number of pages	10 (xsd:int)

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