About: Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy     Goto   Sponge   NotDistinct   Permalink

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Description
  • For protozoan parasites, 6-oxopurine phosphoribosyltransferases (PRTases) provide the only metabolic pathway to synthesize the purine nucleoside monophosphates essential for DNA/RNA production. This enzyme from Plasmodium vivax was cloned, expressed and purified and its properties compared with those of the corresponding enzymes from human and P. falciparum. Several acyclic nucleoside phosphonates were evaluated as inhibitors of PvHGPRT giving Ki values as low as 0.5 .mu.M.
  • For protozoan parasites, 6-oxopurine phosphoribosyltransferases (PRTases) provide the only metabolic pathway to synthesize the purine nucleoside monophosphates essential for DNA/RNA production. This enzyme from Plasmodium vivax was cloned, expressed and purified and its properties compared with those of the corresponding enzymes from human and P. falciparum. Several acyclic nucleoside phosphonates were evaluated as inhibitors of PvHGPRT giving Ki values as low as 0.5 .mu.M. (en)
Title
  • Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy
  • Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy (en)
skos:prefLabel
  • Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy
  • Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy (en)
skos:notation
  • RIV/61388963:_____/10:00345886!RIV11-MSM-61388963
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1M0508), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 279138
http://linked.open...ai/riv/idVysledku
  • RIV/61388963:_____/10:00345886
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • acyclic nucleoside phosphonates; Plasmodium vivax; 6-oxopurine phosphoribosyltransferase (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [39BF74319FFC]
http://linked.open...i/riv/nazevZdroje
  • Molecular and Biochemical Parasitology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 173
http://linked.open...iv/tvurceVysledku
  • Holý, Antonín
  • Hocková, Dana
  • Krečmerová, Marcela
  • Česnek, Michal
  • Guddat, L. W.
  • Keough, D. T.
  • Naesens, L.
  • de Jersey, J.
  • Brereton, I. M.
  • Winzor, D. J.
http://linked.open...ain/vavai/riv/wos
  • 000280659300015
http://linked.open...n/vavai/riv/zamer
issn
  • 0166-6851
number of pages
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