About: Oligomerization of adenosin-5´-O-ylmethylphosphonate, an isopolar AMP analogue: Evaluation of the route to short oligoadenylates

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About: Oligomerization of adenosin-5´-O-ylmethylphosphonate, an isopolar AMP analogue: Evaluation of the route to short oligoadenylates Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In order to prepare a library of short oligoadenylate analogues featuring both the enzyme-stable internucleotide linkage and the 5´-O-methylphosphonate moiety and thus obtain a pool of potential RNase L agonists/antagonists, we studied spontaneous polycondensation of adenosin-5´-O-ylmethylphosphonic acid (pcA), an isopolar AMP analogue, and its imidazolide derivatives employing N,N´-dicyclohexylcarbodiimide under nonaqueousconditions and uranyl ions under aqueous conditions, resp. The RP LC-MS analyses of the reaction mixtures per se, and those obtained after the periodate treatment, along with analyses and separations by capillary zone electrophoresis, allowed for characterization of major linear and cyclic oligoadenylates obtained. Structure of selected compounds was supported, after their isolation, by NMR spectroscopy. In order to prepare a library of short oligoadenylate analogues featuring both the enzyme-stable internucleotide linkage and the 5´-O-methylphosphonate moiety and thus obtain a pool of potential RNase L agonists/antagonists, we studied spontaneous polycondensation of adenosin-5´-O-ylmethylphosphonic acid (pcA), an isopolar AMP analogue, and its imidazolide derivatives employing N,N´-dicyclohexylcarbodiimide under nonaqueousconditions and uranyl ions under aqueous conditions, resp. The RP LC-MS analyses of the reaction mixtures per se, and those obtained after the periodate treatment, along with analyses and separations by capillary zone electrophoresis, allowed for characterization of major linear and cyclic oligoadenylates obtained. Structure of selected compounds was supported, after their isolation, by NMR spectroscopy. (en)
Title	Oligomerization of adenosin-5´-O-ylmethylphosphonate, an isopolar AMP analogue: Evaluation of the route to short oligoadenylates Oligomerization of adenosin-5´-O-ylmethylphosphonate, an isopolar AMP analogue: Evaluation of the route to short oligoadenylates (en)
skos:prefLabel	Oligomerization of adenosin-5´-O-ylmethylphosphonate, an isopolar AMP analogue: Evaluation of the route to short oligoadenylates Oligomerization of adenosin-5´-O-ylmethylphosphonate, an isopolar AMP analogue: Evaluation of the route to short oligoadenylates (en)
skos:notation	RIV/61388963:_____/10:00345878!RIV11-GA0-61388963
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA202/09/0193), P(GA203/09/0820), P(KAN200520801), P(LC06061), P(LC06077), Z(AV0Z40550506), Z(MSM0021620835)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Cvačka, Josef Rosenberg, Ivan Buděšínský, Miloš Kašička, Václav Točík, Zdeněk Kóšiová, Ivana Pressová, Martina Šimák, Ondřej
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	276576
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/10:00345878
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	spontaneous oligomerization; oligoadenylates; phosphonate linkage (en)
http://linked.open.../riv/klicoveSlovo	oligoadenylates phosphonate linkage spontaneous oligomerization
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[522626FD7C2C]
http://linked.open...i/riv/nazevZdroje	Biopolymers
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Cell Invasiveness in Embryonic Development and Tumour Metastases Formation and dynamics of nucleic acid motifs involved in regulation of gene expression Structure based drug design of specific nucleotidases inhibitors, potentially pharmacologically important compounds. Targeted expression and transport of bioactive molecules Center of Chemical Genetics
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	93
http://linked.open...iv/tvurceVysledku	Buděšínský, Miloš Cvačka, Josef Kašička, Václav Rosenberg, Ivan Šimák, Ondřej Kopecký, V. jr. Kóšiová, Ivana Točík, Zdeněk Pressová, Martina
http://linked.open...ain/vavai/riv/wos	000273799000007
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství Fyzika molekulárních, makromolekulárních a biologických systémů
issn	0006-3525
number of pages	13 (xsd:int)

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