About: Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase

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About: Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Structurally diverse, sugar-modified, thymine-containing nucleoside phosphonic acids were evaluated for their ability to inhibit thymidine phosphorylase purified from spontaneous T-cell lymphomas of an inbred Sprague-Dawley rat strain. From a large set of tested compounds, among them a number of pyrrolidine-based derivatives, 10 nucleotide analogues with IC50 values below 1 .mu.M were selected. Out of them, four compounds strongly inhibited the enzyme with IC50 values in a range of 11–45 nM. These most potent compounds might be bi-substrate analogues. Structurally diverse, sugar-modified, thymine-containing nucleoside phosphonic acids were evaluated for their ability to inhibit thymidine phosphorylase purified from spontaneous T-cell lymphomas of an inbred Sprague-Dawley rat strain. From a large set of tested compounds, among them a number of pyrrolidine-based derivatives, 10 nucleotide analogues with IC50 values below 1 .mu.M were selected. Out of them, four compounds strongly inhibited the enzyme with IC50 values in a range of 11–45 nM. These most potent compounds might be bi-substrate analogues. (en)
Title	Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase (en)
skos:prefLabel	Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase (en)
skos:notation	RIV/61388963:_____/10:00345860!RIV11-GA0-61388963
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1QS400550501), P(2B06065), P(GA202/09/0193), P(GA203/09/0820), P(KAN200520801), P(LC06061), P(LC06077), P(NR9138), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Votruba, Ivan Rinnová, Markéta Kočalka, Petr Rosenberg, Ivan Petrová, Magdalena Buděšínský, Miloš Pohl, Radek Rejman, Dominik Točík, Zdeněk Králíková, Šárka Páv, Ondřej Poláková, Ivana Liboska, Radek Vaněk, Václav Panova, Natalya
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	290435
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/10:00345860
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	phosphonate nucleotides; pyrrolidine; thymidine phosphorylase (en)
http://linked.open.../riv/klicoveSlovo	thymidine phosphorylase phosphonate nucleotides pyrrolidine
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[98036BCFC18F]
http://linked.open...i/riv/nazevZdroje	Bioorganic and Medicinal Chemistry Letters
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	15 (xsd:int)
http://linked.open...cetTvurcuVysledku	15 (xsd:int)
http://linked.open...vavai/riv/projekt	New Generation of Antibacterial Agens Center of Cell Invasiveness in Embryonic Development and Tumour Metastases Novel antivirals and antineoplastics Inhibitors of Bacterial RNA Polymerase Based on Nucleotide Analogues Formation and dynamics of nucleic acid motifs involved in regulation of gene expression Structure based drug design of specific nucleotidases inhibitors, potentially pharmacologically important compounds. Targeted expression and transport of bioactive molecules Center of Chemical Genetics
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	20
http://linked.open...iv/tvurceVysledku	Buděšínský, Miloš Petrová, Magdalena Pohl, Radek Rosenberg, Ivan Votruba, Ivan Vaněk, Václav Rejman, Dominik Králíková, Šárka Panova, Natalya Páv, Ondřej Točík, Zdeněk Liboska, Radek Kočalka, Petr Rinnová, Markéta Tomečková, Ivana
http://linked.open...ain/vavai/riv/wos	000273783800014
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	0960-894X
number of pages	4 (xsd:int)

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