About: Sonogashira reactions of alpha and beta-1-ethynyl-2-deoxyribosides: synthesis of acetylene-extended C-nucleosides

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About: Sonogashira reactions of alpha and beta-1-ethynyl-2-deoxyribosides: synthesis of acetylene-extended C-nucleosides Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	An improved practical protocol for the synthesis of both anomers of 1-ethynyl-2-deoxiribosides 1 was developed. The Sonogashira coupling of ethynyldeoxyribosides 1 with vatious aryl- and heteroaryl halides was carried out under various conditions. It was found that the use of copper-free coupling protocols could reduce the oxidative dimerisation in favour of arylalkynyldeoxyriboside formation. An improved practical protocol for the synthesis of both anomers of 1-ethynyl-2-deoxiribosides 1 was developed. The Sonogashira coupling of ethynyldeoxyribosides 1 with vatious aryl- and heteroaryl halides was carried out under various conditions. It was found that the use of copper-free coupling protocols could reduce the oxidative dimerisation in favour of arylalkynyldeoxyriboside formation. (en)
Title	Sonogashira reactions of alpha and beta-1-ethynyl-2-deoxyribosides: synthesis of acetylene-extended C-nucleosides Sonogashira reactions of alpha and beta-1-ethynyl-2-deoxyribosides: synthesis of acetylene-extended C-nucleosides (en)
skos:prefLabel	Sonogashira reactions of alpha and beta-1-ethynyl-2-deoxyribosides: synthesis of acetylene-extended C-nucleosides Sonogashira reactions of alpha and beta-1-ethynyl-2-deoxyribosides: synthesis of acetylene-extended C-nucleosides (en)
skos:notation	RIV/61388963:_____/10:00342975!RIV11-MSM-61388963
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(1M0508), P(IAA400550902), S, Z(AV0Z40550506), Z(MSM0021620857)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Hocek, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	288644
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/10:00342975
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	alkynes; C-nucleosides; aryl halides; cross-coupling reactions (en)
http://linked.open.../riv/klicoveSlovo	aryl halides cross-coupling reactions C-nucleosides alkynes
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[1029DF4C33CF]
http://linked.open...i/riv/nazevZdroje	Tetrahedron
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	New Antivirals and Antineoplastics Development of modular syntheses of new C-nucleosides for studying DNA polymerase specificity and for the extension of the genetic alphabet
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	66
http://linked.open...iv/tvurceVysledku	Hocek, Michal Kotora, M. Bobula, T.
http://linked.open...ain/vavai/riv/wos	000273923300015
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství Nové molekulární systémy pro pokročilé aplikace prospěšné pro zdraví a šetrné k životnímu prostředí
issn	0040-4020
number of pages	7 (xsd:int)

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