About: Inhibitors of N (alpha)-acetyl-L-ornithine deacetylase: synthesis, characterization and analysis of their inhibitory potency

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About: Inhibitors of N (alpha)-acetyl-L-ornithine deacetylase: synthesis, characterization and analysis of their inhibitory potency Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A series of Nα-acyl(alkyl) and N (alpha)-alkoxycarbonyl-derivatives of L- and D-ornithine were prepared, characterized and analyzed for their potency toward the bacterial enzyme N (alpha)-acetyl-L-ornithine deacetylase. N (alpha)-chloroacetyl-L-ornithine was the best inhibitor tested providing an IC50 value of 85 (mu)M. A series of Nα-acyl(alkyl) and N (alpha)-alkoxycarbonyl-derivatives of L- and D-ornithine were prepared, characterized and analyzed for their potency toward the bacterial enzyme N (alpha)-acetyl-L-ornithine deacetylase. N (alpha)-chloroacetyl-L-ornithine was the best inhibitor tested providing an IC50 value of 85 (mu)M. (en)
Title	Inhibitors of N (alpha)-acetyl-L-ornithine deacetylase: synthesis, characterization and analysis of their inhibitory potency Inhibitors of N (alpha)-acetyl-L-ornithine deacetylase: synthesis, characterization and analysis of their inhibitory potency (en)
skos:prefLabel	Inhibitors of N (alpha)-acetyl-L-ornithine deacetylase: synthesis, characterization and analysis of their inhibitory potency Inhibitors of N (alpha)-acetyl-L-ornithine deacetylase: synthesis, characterization and analysis of their inhibitory potency (en)
skos:notation	RIV/61388963:_____/10:00342427!RIV11-AV0-61388963
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAA400550614), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Slaninová, Jiřina Fučík, Vladimír Buděšínský, Miloš Jiráček, Jiří Pícha, Jan Hlaváček, Jan Vaněk, Václav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	264010
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/10:00342427
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ArgE inhibitors; acetylornithine derivatives; synthesis; inhibitory and antiviral activity (en)
http://linked.open.../riv/klicoveSlovo	ArgE inhibitors acetylornithine derivatives inhibitory and antiviral activity synthesis
http://linked.open...odStatuVydavatele	AT - Rakouská republika
http://linked.open...ontrolniKodProRIV	[720A0A9848CA]
http://linked.open...i/riv/nazevZdroje	Amino Acids
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Synthesis and characterization of new potent inhibitors of enzymes dapE and argE with selective antimicrobial effect on resistant pathogenic bacterial strains
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	38
http://linked.open...iv/tvurceVysledku	Buděšínský, Miloš Fučík, Vladimír Hlaváček, Jan Slaninová, Jiřina Vaněk, Václav Pícha, Jan Jiráček, Jiří Gilner, D. Holz, R. C.
http://linked.open...ain/vavai/riv/wos	000276423300020
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	0939-4451
number of pages	10 (xsd:int)

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