About: 6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic Agents     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
Description
  • A series of novel 7-deazapurine ribonucleosides bearing an alkyl, aryl or hetaryl group in position 6 and H, F, or Cl atom in position 7 has been prepared and showed to possess significant cytostatic effect in nanomolar concentrations. Intracellular phosphorylation to mono- and triphosphates, and the inhibition of total RNA synthesis was demonstrated in preliminary study of metabolism and mechanism of action studies.
  • A series of novel 7-deazapurine ribonucleosides bearing an alkyl, aryl or hetaryl group in position 6 and H, F, or Cl atom in position 7 has been prepared and showed to possess significant cytostatic effect in nanomolar concentrations. Intracellular phosphorylation to mono- and triphosphates, and the inhibition of total RNA synthesis was demonstrated in preliminary study of metabolism and mechanism of action studies. (en)
Title
  • 6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic Agents
  • 6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic Agents (en)
skos:prefLabel
  • 6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic Agents
  • 6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic Agents (en)
skos:notation
  • RIV/61388963:_____/10:00342338!RIV11-MSM-61388963
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1M0508), P(1QS400550501), S, Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 301043
http://linked.open...ai/riv/idVysledku
  • RIV/61388963:_____/10:00342338
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • nucleosides; 7-deazapurines; cross-coupling; cytostatic activity (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [23E63D2BAA98]
http://linked.open...i/riv/nazevZdroje
  • Journal of Medicinal Chemistry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 53
http://linked.open...iv/tvurceVysledku
  • Cihlar, T.
  • Hocek, Michal
  • Mackman, R.
  • Pohl, Radek
  • Votruba, Ivan
  • Birkuš, G.
  • Džubák, P.
  • Hajdúch, M.
  • Nauš, Petr
  • Ray, A. S.
  • Wang, T.
  • Ameral, R.
http://linked.open...ain/vavai/riv/wos
  • 000273268300039
http://linked.open...n/vavai/riv/zamer
issn
  • 0022-2623
number of pages
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 38 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software