About: Current and Novel Inhibitors of HIV Protease

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	This review describes all nine currently available FDA-approved protease inhibitors, discusses their pharmacokinetic properties, off-target activities, side-effects, and resistance profiles. The compounds in the various stages of clinical development are also introduced, as well as alternative approaches, aiming at other functional domains of HIV PR. The potential of these novel compounds to open new way to the rational drug design of human viruses is critically assessed. This review describes all nine currently available FDA-approved protease inhibitors, discusses their pharmacokinetic properties, off-target activities, side-effects, and resistance profiles. The compounds in the various stages of clinical development are also introduced, as well as alternative approaches, aiming at other functional domains of HIV PR. The potential of these novel compounds to open new way to the rational drug design of human viruses is critically assessed. (en)
Title	Current and Novel Inhibitors of HIV Protease Current and Novel Inhibitors of HIV Protease (en)
skos:prefLabel	Current and Novel Inhibitors of HIV Protease Current and Novel Inhibitors of HIV Protease (en)
skos:notation	RIV/61388963:_____/09:00336551!RIV11-MSM-61388963
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0508), P(IAAX00320901), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Řezáčová, Pavlína Pokorná, Jana Konvalinka, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	308700
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/09:00336551
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HIV protease; protease inhibitor; HAART (en)
http://linked.open.../riv/klicoveSlovo	HIV protease HAART protease inhibitor
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[4D689E9622CF]
http://linked.open...i/riv/nazevZdroje	Viruses
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Functionalized boron clusters as viral enzyme inhihitors New Antivirals and Antineoplastics
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	1
http://linked.open...iv/tvurceVysledku	Konvalinka, Jan Pokorná, Jana Řezáčová, Pavlína Machala, L.
http://linked.open...ain/vavai/riv/wos	000280413200044
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	1999-4915
number of pages	31 (xsd:int)

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