About: Mechanism of formation of (deoxy)guanosine adducts derived from peroxidase-catalyzed oxidation of the carcinogenic nonaminoazo dye 1-phenylazo-2-hydroxynaphthalene (Sudan I)

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About: Mechanism of formation of (deoxy)guanosine adducts derived from peroxidase-catalyzed oxidation of the carcinogenic nonaminoazo dye 1-phenylazo-2-hydroxynaphthalene (Sudan I) Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We investigated peroxidase-mediated oxidation of and (deoxy)guanosine adduct formation by 1-phenylazo-2-hydroxynaphthalene (Sudan I), a liver and urinary bladder carcinogen for rodents. Using TLC and/or HPLC combined with mass and/or NMR spectrometry, we characterized the structures of two major peroxidase-mediated Sudan I metabolites and those of adducts of (deoxy)guanosine that are formed during Sudan I oxidation. We investigated peroxidase-mediated oxidation of and (deoxy)guanosine adduct formation by 1-phenylazo-2-hydroxynaphthalene (Sudan I), a liver and urinary bladder carcinogen for rodents. Using TLC and/or HPLC combined with mass and/or NMR spectrometry, we characterized the structures of two major peroxidase-mediated Sudan I metabolites and those of adducts of (deoxy)guanosine that are formed during Sudan I oxidation. (en)
Title	Mechanism of formation of (deoxy)guanosine adducts derived from peroxidase-catalyzed oxidation of the carcinogenic nonaminoazo dye 1-phenylazo-2-hydroxynaphthalene (Sudan I) Mechanism of formation of (deoxy)guanosine adducts derived from peroxidase-catalyzed oxidation of the carcinogenic nonaminoazo dye 1-phenylazo-2-hydroxynaphthalene (Sudan I) (en)
skos:prefLabel	Mechanism of formation of (deoxy)guanosine adducts derived from peroxidase-catalyzed oxidation of the carcinogenic nonaminoazo dye 1-phenylazo-2-hydroxynaphthalene (Sudan I) Mechanism of formation of (deoxy)guanosine adducts derived from peroxidase-catalyzed oxidation of the carcinogenic nonaminoazo dye 1-phenylazo-2-hydroxynaphthalene (Sudan I) (en)
skos:notation	RIV/61388963:_____/09:00332891!RIV10-AV0-61388963
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/09/0812), P(GA303/09/0472), P(KJB400550903), Z(AV0Z40550506), Z(MSM0021620808)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Cvačka, Josef Dračínský, Martin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	325188
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/09:00332891
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Sudan I; peroxidase; NMR spectroscopy; (deoxy)guanosin adducts (en)
http://linked.open.../riv/klicoveSlovo	Sudan I NMR spectroscopy peroxidase (deoxy)guanosin adducts
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[4BEEDC0F0475]
http://linked.open...i/riv/nazevZdroje	Chemical Research in Toxicology
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Mechanism of modulation of cytochrome P450 1A1/2 mediated oxidation of drugs and carcinogens by cytochrome b5; experimental and computational approach Study on participation of biotransformation enzymes in development of renal injury and urothelial cancer mediated by aristolochic acid Study of isotopic exchange of hydrogen in the position 5 of pyrimidine derivatives and synthesis of pyrimidines with biological activity labeled with tritium.
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	22
http://linked.open...iv/tvurceVysledku	Cvačka, Josef Dračínský, Martin Frei, E. Stiborová, M. Martínek, V. Semanská, M.
http://linked.open...ain/vavai/riv/wos	000271654100003
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství Molekulárně biologické, genetické a epigenetické aspekty vzniku a rozvoje modelových tumorů dospělého věku. Význam pro epidemiologii, časnou diagnostiku a léčbu
issn	0893-228X
number of pages	9 (xsd:int)

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