About: The strand transfer oligonucleotide inhibitors of HIV-integrase

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We have designed and synthesized oligonucleotides (ONs) of various lengths that mimic the processed HIV-1 U5 terminus of the proviral long terminal repeat (LTR) and are ended by 2-deoxyadenosine containing a 3-O-phosphonomethyl group for inhibition of HIV-1 integrase. The duplex stability of phosphonomethyl ONs was increased by covalent linkage of the modified strand with its complementary strand by a triethylene glycol loop (TEG). Modified ONs containing up to 10 bases inhibited in vitro the strand transfer reaction catalyzed by HIV-1 integrase at nanomolar concentrations. We have designed and synthesized oligonucleotides (ONs) of various lengths that mimic the processed HIV-1 U5 terminus of the proviral long terminal repeat (LTR) and are ended by 2-deoxyadenosine containing a 3-O-phosphonomethyl group for inhibition of HIV-1 integrase. The duplex stability of phosphonomethyl ONs was increased by covalent linkage of the modified strand with its complementary strand by a triethylene glycol loop (TEG). Modified ONs containing up to 10 bases inhibited in vitro the strand transfer reaction catalyzed by HIV-1 integrase at nanomolar concentrations. (en)
Title	The strand transfer oligonucleotide inhibitors of HIV-integrase The strand transfer oligonucleotide inhibitors of HIV-integrase (en)
skos:prefLabel	The strand transfer oligonucleotide inhibitors of HIV-integrase The strand transfer oligonucleotide inhibitors of HIV-integrase (en)
skos:notation	RIV/61388963:_____/09:00327524!RIV10-MSM-61388963
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0508), P(GA203/05/0827), P(GP203/05/P557), P(IAA4055304), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Pačes, Ondřej Rosenberg, Ivan Pichová, Iva Snášel, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	343937
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/09:00327524
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HIV-1 integrase; inhibition; phosphonate oligonucleotides (en)
http://linked.open.../riv/klicoveSlovo	inhibition HIV-1 integrase phosphonate oligonucleotides
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[B9BBF2E9F69C]
http://linked.open...i/riv/nazevZdroje	Journal of Enzyme Inhibition and Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	New Antivirals and Antineoplastics Isopolar phosphonate oligonucleotides as alternative to phosphorothioate ones in regulation of gene expression Study of integrase and pre-integration complex of monkey retrovirus Structural study of protein domains of monkey retrovirus
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	24
http://linked.open...iv/tvurceVysledku	Pichová, Iva Rosenberg, Ivan Snášel, Jan Pačes, Ondřej
http://linked.open...ain/vavai/riv/wos	000262718700034
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	1475-6366
number of pages	6 (xsd:int)

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