About: Antibody response to the 45 kDa Candida albicans antigen in an animal model and potential role of the antigen in adherence

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About: Antibody response to the 45 kDa Candida albicans antigen in an animal model and potential role of the antigen in adherence Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Byl identifikován protein CR3-RP (protein podobný CR3 adhéznímu receptoru) u C. albicans. Blokování tohoto proteinu polyklonálními protilátkami snížilo schopnost C. albicans adherovat k bukálním epiteliálním buňkám a ovlivnilo tvorbu a tloušťku biofilmu, pozorovanou skenovacím konfokálním mikroskopem. Tyto výsledky ukazují, že CR3-RP by mohl sloužit pro vývoj vakcíny. (cs) The Candida antigen CR3-RP (complement receptor 3-related protein) was identified and characterized as a 'mimicry' protein, which might play a role in the adherence of Candida albicans. Blocking CR3-RP with polyclonal anti-CR3-RP serum reduced the ability of Candida to adhere to buccal epithelial cells and formation of biofilm by 28% (P,0.001), including changes in biofilm thickness and integrity detected by confocal laser scanning microscopy. These properties of CR3-RP suggest that it has potential for future vaccine development. The Candida antigen CR3-RP (complement receptor 3-related protein) was identified and characterized as a 'mimicry' protein, which might play a role in the adherence of Candida albicans. Blocking CR3-RP with polyclonal anti-CR3-RP serum reduced the ability of Candida to adhere to buccal epithelial cells and formation of biofilm by 28% (P,0.001), including changes in biofilm thickness and integrity detected by confocal laser scanning microscopy. These properties of CR3-RP suggest that it has potential for future vaccine development. (en)
Title	Antibody response to the 45 kDa Candida albicans antigen in an animal model and potential role of the antigen in adherence Účinek protilatek proti 45 kDa proteinovému antigenu z Candidy albicans ve zvířecím modelu a jeho potenciální role v adherenci (cs) Antibody response to the 45 kDa Candida albicans antigen in an animal model and potential role of the antigen in adherence (en)
skos:prefLabel	Antibody response to the 45 kDa Candida albicans antigen in an animal model and potential role of the antigen in adherence Účinek protilatek proti 45 kDa proteinovému antigenu z Candidy albicans ve zvířecím modelu a jeho potenciální role v adherenci (cs) Antibody response to the 45 kDa Candida albicans antigen in an animal model and potential role of the antigen in adherence (en)
skos:notation	RIV/61388963:_____/08:00316278!RIV09-AV0-61388963
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LC531), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Pichová, Iva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	356401
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/08:00316278
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	candida albicans; CR3-RP antigen; adherence (en)
http://linked.open.../riv/klicoveSlovo	adherence CR3-RP antigen candida albicans
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[BD1DF8C77699]
http://linked.open...i/riv/nazevZdroje	Journal of Medical Microbiology
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre on molecular biology and physiology of yeast communities
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	57
http://linked.open...iv/tvurceVysledku	Pichová, Iva Chorvát, D. Borecká-Melkusová, S. Bujdáková, J. Gašperík, J. Jensen, D. B. Kolecká, A. Kucharíková, S. Lell, C. Paulovičová, E. Würzner, R.
http://linked.open...ain/vavai/riv/wos	000261660600003
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	0022-2615
number of pages	7 (xsd:int)

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