About: Mechanism of antiviral drug resistance of vaccinia virus: Identification of residues in the viral DNA polymerase conferring differential resistance to anti-poxvirus drugs     Goto   Sponge   NotDistinct   Permalink

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Description
  • Byly vytvořeny mutanty viru vakcinie resistentní k (S)-HPMPDAP. Všechny z těchto virových mutantů ještě vykazovaly různý stupeň snížené virulence u myšího modelu při intranasální aplikaci. Infekce způsobené těmito k léčivům resistentními viry byly u myší ještě stále léčitelné vyššími dávkami acyklických nukleosidfosfonátů. (cs)
  • S-HPMPDAP-resistant vaccinia virus mutants were generated. All of the mutant viruses still exhibited a variable degree of reduced virulence in a mouse intranasal challenge model. Infections caused by these drug-resistant viruses in mice were still treatable with higher concentrations of the ANPs.
  • S-HPMPDAP-resistant vaccinia virus mutants were generated. All of the mutant viruses still exhibited a variable degree of reduced virulence in a mouse intranasal challenge model. Infections caused by these drug-resistant viruses in mice were still treatable with higher concentrations of the ANPs. (en)
Title
  • Mechanism of antiviral drug resistance of vaccinia virus: Identification of residues in the viral DNA polymerase conferring differential resistance to anti-poxvirus drugs
  • Mechanism of antiviral drug resistance of vaccinia virus: Identification of residues in the viral DNA polymerase conferring differential resistance to anti-poxvirus drugs (en)
  • Mechanismus resistence viru vakcinie vůči protivirovým látkám: Identifikace zbytků ve virové DNA polymerase udělujících rozdílnou resistenci k léčivům proti poxvirům (cs)
skos:prefLabel
  • Mechanism of antiviral drug resistance of vaccinia virus: Identification of residues in the viral DNA polymerase conferring differential resistance to anti-poxvirus drugs
  • Mechanism of antiviral drug resistance of vaccinia virus: Identification of residues in the viral DNA polymerase conferring differential resistance to anti-poxvirus drugs (en)
  • Mechanismus resistence viru vakcinie vůči protivirovým látkám: Identifikace zbytků ve virové DNA polymerase udělujících rozdílnou resistenci k léčivům proti poxvirům (cs)
skos:notation
  • RIV/61388963:_____/08:00315205!RIV09-AV0-61388963
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1M0508), P(1QS400550501), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika
  • 24
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 378289
http://linked.open...ai/riv/idVysledku
  • RIV/61388963:_____/08:00315205
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • vaccinia; drug resistence; poxivirus; acyclic nucleoside phosphonates; (S)-HPMPDAP (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [D18C23F6896D]
http://linked.open...i/riv/nazevZdroje
  • Journal of Virology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 82
http://linked.open...iv/tvurceVysledku
  • Andrei, G.
  • Holý, Antonín
  • Krečmerová, Marcela
  • Snoeck, R.
  • De Clercq, E.
  • Fiten, P.
  • Opdenakker, G.
  • Evans, D. H.
  • Gammon, D. B.
http://linked.open...ain/vavai/riv/wos
  • 000261164000051
http://linked.open...n/vavai/riv/zamer
issn
  • 0022-538X
number of pages
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