About: Nucleosides and nucleotides containing 8-aza-7,9-dideazaxanthine     Goto   Sponge   NotDistinct   Permalink

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Description
  • 8-Aza-7,9-dideazaxanthin byl připraven pomocí TosMIC a 1,3-dibenzyluracilu. Postup byl vylepšen užitím AlCl3 pro finální debenzylaci. 8-Alkyl-8-aza-7,9-dideazaxanthiny byly připraveny reakcí 6-dibromomethyl-5-formyluracilu s benzyl-, 4 methoxybenzyl-, a 1 adamantylaminem. Bylo zjištěno že N1- a N8-(8-fosfonooktyl)-8-aza-7,9-dideazaxanthin jsou učinnými inhibitory thymidin fosforylasy (V79 buňky, lidská placenta, Escherichia coli). Hodnoty IC50 3–27 .mu.M. (cs)
  • The described preparation of 8-aza-7,9-dideazaxanthine from 1,3-dibenzyluracil and TosMIC was improved by using AlCl3 for final debenzylation. Treatment of 6-dibromomethyl- 5-formyluracil with benzyl-, 4-methoxybenzyl-, and 1-adamantylamine gave the corresponding 8-alkyl-8-aza-7,9-dideazaxanthines. N1- and N8-(8-phosphonooctyl)-8-aza-7,9-dideazaxanthines were prepared and found as inhibitors of thymidine phosphorylase (V79 cells, human placenta, Escherichia coli). IC50 values ranged at 3–27 .mu.M.
  • The described preparation of 8-aza-7,9-dideazaxanthine from 1,3-dibenzyluracil and TosMIC was improved by using AlCl3 for final debenzylation. Treatment of 6-dibromomethyl- 5-formyluracil with benzyl-, 4-methoxybenzyl-, and 1-adamantylamine gave the corresponding 8-alkyl-8-aza-7,9-dideazaxanthines. N1- and N8-(8-phosphonooctyl)-8-aza-7,9-dideazaxanthines were prepared and found as inhibitors of thymidine phosphorylase (V79 cells, human placenta, Escherichia coli). IC50 values ranged at 3–27 .mu.M. (en)
Title
  • Nucleosides and nucleotides containing 8-aza-7,9-dideazaxanthine
  • Nukleosidy a nukleotidy obsahující 8-aza-7,9-dideazaxanthin (cs)
  • Nucleosides and nucleotides containing 8-aza-7,9-dideazaxanthine (en)
skos:prefLabel
  • Nucleosides and nucleotides containing 8-aza-7,9-dideazaxanthine
  • Nukleosidy a nukleotidy obsahující 8-aza-7,9-dideazaxanthin (cs)
  • Nucleosides and nucleotides containing 8-aza-7,9-dideazaxanthine (en)
skos:notation
  • RIV/61388963:_____/08:00310039!RIV09-AV0-61388963
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1M0508), P(1QS400550501), Z(AV0Z40550506)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 383413
http://linked.open...ai/riv/idVysledku
  • RIV/61388963:_____/08:00310039
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • 8-Aza-7,9-dideaza; xanthine; thymidine phosporylase; debenzylation (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [4B7E0AA58DCB]
http://linked.open...v/mistoKonaniAkce
  • Český Krumlov
http://linked.open...i/riv/mistoVydani
  • Praha
http://linked.open...i/riv/nazevZdroje
  • Chemistry of Nucleic Acid Components
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Dračínský, Martin
  • Holý, Antonín
  • Votruba, Ivan
  • Otmar, Miroslav
  • Mařák, David
http://linked.open...vavai/riv/typAkce
http://linked.open...ain/vavai/riv/wos
  • 000257885700102
http://linked.open.../riv/zahajeniAkce
http://linked.open...n/vavai/riv/zamer
number of pages
http://purl.org/ne...btex#hasPublisher
  • Institute of Organic Chemistry and Biochemistry ASCR
https://schema.org/isbn
  • 978-80-86241-29-6
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