About: A modular methodology for the synthesis of 3- and 4- substituted benzene and aniline C-ribonucleosides     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
Description
  • A novel modular, efficient and practical methodology for the preparation of 3- and 4-substituted phenyl and aniline C-ribonucleosides was developed. The key intermediates were synthesized in two steps from TBS-protected ribonolactone in 75% and 66% yields, respectively, as pure beta-anomers. The bromophenyl intermediates were subjected to a series of palladium catalyzed cross-coupling, aminations and alkoxylation reactions to give, after deprotection a series of free 1 beta-(3- and 4-alkyl, -aryl, -amino -alkoxyphenyl and -hetaryl substituted phenyl)-C-ribonucleosides (20 examples).
  • A novel modular, efficient and practical methodology for the preparation of 3- and 4-substituted phenyl and aniline C-ribonucleosides was developed. The key intermediates were synthesized in two steps from TBS-protected ribonolactone in 75% and 66% yields, respectively, as pure beta-anomers. The bromophenyl intermediates were subjected to a series of palladium catalyzed cross-coupling, aminations and alkoxylation reactions to give, after deprotection a series of free 1 beta-(3- and 4-alkyl, -aryl, -amino -alkoxyphenyl and -hetaryl substituted phenyl)-C-ribonucleosides (20 examples). (en)
  • Byla vyvinuta nová modulární, efektivní a praktická syntéza 3- a 4-substituovaných fenylových a anilinových C-ribonukleosidů. Oba klíčové intermediáty byly syntetizovány ve dvou krocích, vycházející z TBS-chráněného ribonolaktonu, v 75% a 66% výtěžku jako čisté beta-anomery. 3- a 4-bromfenylové intermediáty přetransformované pomocí palladiem katalyzovaných cross-coupling, aminačních a alkoxylačních reakcí, poskytly po následné deprotekci volné 1 beta-(3- a 4-alkyl, -aryl, -amino, -alkoxyfenyl a -hetaryl substituované fenyl)-C-ribonukleosidy (20 příkladů). (cs)
Title
  • A modular methodology for the synthesis of 3- and 4- substituted benzene and aniline C-ribonucleosides
  • A modular methodology for the synthesis of 3- and 4- substituted benzene and aniline C-ribonucleosides (en)
  • Modulární metodika na přípravu 3- a 4- substituovaných benzenových a anilínových C-ribonukleosidů (cs)
skos:prefLabel
  • A modular methodology for the synthesis of 3- and 4- substituted benzene and aniline C-ribonucleosides
  • A modular methodology for the synthesis of 3- and 4- substituted benzene and aniline C-ribonucleosides (en)
  • Modulární metodika na přípravu 3- a 4- substituovaných benzenových a anilínových C-ribonukleosidů (cs)
skos:notation
  • RIV/61388963:_____/08:00309932!RIV09-AV0-61388963
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(LC512), Z(AV0Z40550506)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 354261
http://linked.open...ai/riv/idVysledku
  • RIV/61388963:_____/08:00309932
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • cross-coupling reactions; C-nucleosides; amination reactions; benzenes (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [DAF95EADA231]
http://linked.open...v/mistoKonaniAkce
  • Český Krumlov
http://linked.open...i/riv/mistoVydani
  • Praha
http://linked.open...i/riv/nazevZdroje
  • Chemistry of Nucleic Acid Components
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Hocek, Michal
  • Štefko, Martin
http://linked.open...vavai/riv/typAkce
http://linked.open...ain/vavai/riv/wos
  • 000257885700112
http://linked.open.../riv/zahajeniAkce
http://linked.open...n/vavai/riv/zamer
number of pages
http://purl.org/ne...btex#hasPublisher
  • Institute of Organic Chemistry and Biochemistry ASCR
https://schema.org/isbn
  • 978-80-86241-29-6
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 38 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software