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Description
  • A novel approach to the synthesis of (purin-6-yl)acetates was developed based on Pd-catalysed cross-coupling reactions of 6-chloropurines with the Reformatsky agent. These intermediates were converted into various products by functional group transformations. Amides were prepared by amidation of ester group with amines, 6-(hydroxyethyl)purines by reduction by NaBH4, and beta-substituted 6-ethylpurines by mesylation of 6-(hydroxyethyl)purines and subsequent nucleophilic substitution.
  • A novel approach to the synthesis of (purin-6-yl)acetates was developed based on Pd-catalysed cross-coupling reactions of 6-chloropurines with the Reformatsky agent. These intermediates were converted into various products by functional group transformations. Amides were prepared by amidation of ester group with amines, 6-(hydroxyethyl)purines by reduction by NaBH4, and beta-substituted 6-ethylpurines by mesylation of 6-(hydroxyethyl)purines and subsequent nucleophilic substitution. (en)
  • Byla vyvinut nový přístup k syntéze (purin-6-yl)acetátů založen na palladiem katalyzovaných cross-coupling reakcích 6-chlorpurinu s Reformackého činidlem. Tyto intermediáty byly přeměněny na další látky transformacemi funkčních skupin. Amidy byly připraveny amidacemi esterové skupiny, 6-(hydroxyethyl)puriny byly redukovány pomocí NaBH4, a beta-substituované 6-ethylpuriny byly připraveny mesylací 6-(hydroxyethyl)purinů a jejich následnou nukleofilní substitucí. (cs)
Title
  • Synthesis of (purin-6-yl)acetates and their transformations
  • Synthesis of (purin-6-yl)acetates and their transformations (en)
  • Syntéza (purin-6-yl)acetátů a jejich transformace (cs)
skos:prefLabel
  • Synthesis of (purin-6-yl)acetates and their transformations
  • Synthesis of (purin-6-yl)acetates and their transformations (en)
  • Syntéza (purin-6-yl)acetátů a jejich transformace (cs)
skos:notation
  • RIV/61388963:_____/08:00309920!RIV09-AV0-61388963
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1M0508), P(1QS400550501), Z(AV0Z40550506)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 398795
http://linked.open...ai/riv/idVysledku
  • RIV/61388963:_____/08:00309920
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • purines; nucleosides; cross-coupling (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [2F7ECEB16E24]
http://linked.open...v/mistoKonaniAkce
  • Český Krumlov
http://linked.open...i/riv/mistoVydani
  • Praha
http://linked.open...i/riv/nazevZdroje
  • Chemistry of Nucleic Acid Components
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Hocek, Michal
  • Hasník, Zbyněk
http://linked.open...vavai/riv/typAkce
http://linked.open...ain/vavai/riv/wos
  • 000257885700075
http://linked.open.../riv/zahajeniAkce
http://linked.open...n/vavai/riv/zamer
number of pages
http://purl.org/ne...btex#hasPublisher
  • Institute of Organic Chemistry and Biochemistry ASCR
https://schema.org/isbn
  • 978-80-86241-29-6
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