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rdf:type
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Description
| - Byla vyvinuta modulární metodika pro přípravu různě substituovaných aryl C-2´-deoxyribonukleosidů. V každé sérii byla vypracována syntetická metodika pro multi-gramovou přípravu klíčového halogenovaného intermediátu, který byl následně přetransformován pomocí cross-coupling reakcí na příslušné alkyl, aryl a amino substituované deriváty. Následné odchránění poskytlo požadované volné C-2´-deoxyribonukleosidy. Tato metodika byla aplikována pro modulární syntézu 4- nebo 3-substituovaných benzen C-nukleosidů, 6-substituovaných pyridin-2-yl C-nukleosidů, 6-substituovaných pyridin-3-yl C-nukleosidů a 5-substituovaných thiofen-2-yl C-nukleosidů. (cs)
- A modular methodology for the syntheses of various substituted aryl C-2´-deoxyribonucleosides has been developed. In each series, a larger scale synthesis of a versatile halogenated C-nucleoside intermediate has been accomplished, followed by its use for a generation of diverse derivatives by displacement of the halogen for alkyl, aryl or amino substituents by cross-coupling or amination reactions. Subsequent deprotection gave the final desired C-2´-deoxyribonucleosides. This methodology has been applied for the development of modular syntheses of 4- or 3-substituted benzene C-nucleosides, 6-substituted pyridin-2-yl C-nucleosides, 6-substituted pyridin-3-yl C-nucleosides and 5-substituted thiophen-2-yl C-nucleosides.
- A modular methodology for the syntheses of various substituted aryl C-2´-deoxyribonucleosides has been developed. In each series, a larger scale synthesis of a versatile halogenated C-nucleoside intermediate has been accomplished, followed by its use for a generation of diverse derivatives by displacement of the halogen for alkyl, aryl or amino substituents by cross-coupling or amination reactions. Subsequent deprotection gave the final desired C-2´-deoxyribonucleosides. This methodology has been applied for the development of modular syntheses of 4- or 3-substituted benzene C-nucleosides, 6-substituted pyridin-2-yl C-nucleosides, 6-substituted pyridin-3-yl C-nucleosides and 5-substituted thiophen-2-yl C-nucleosides. (en)
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Title
| - Modular methodology for the synthesis of various aryl C-2'-deoxyribonucleosides
- Modular methodology for the synthesis of various aryl C-2'-deoxyribonucleosides (en)
- Modulární metodiky pro přípravu různých aryl C-2'-deoxyribonukleosidů (cs)
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skos:prefLabel
| - Modular methodology for the synthesis of various aryl C-2'-deoxyribonucleosides
- Modular methodology for the synthesis of various aryl C-2'-deoxyribonucleosides (en)
- Modulární metodiky pro přípravu různých aryl C-2'-deoxyribonukleosidů (cs)
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skos:notation
| - RIV/61388963:_____/08:00309902!RIV09-AV0-61388963
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(LC512), Z(AV0Z40550506)
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61388963:_____/08:00309902
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - modular methodology; C-2'-deoxyribonucleosides; benzene; pyridin; thiophenyl (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...v/mistoKonaniAkce
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http://linked.open...i/riv/mistoVydani
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http://linked.open...i/riv/nazevZdroje
| - Chemistry of Nucleic Acid Components
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...iv/tvurceVysledku
| - Bárta, Jan
- Hocek, Michal
- Joubert, Nicolas
- Urban, Milan
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http://linked.open...vavai/riv/typAkce
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http://linked.open...ain/vavai/riv/wos
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http://linked.open.../riv/zahajeniAkce
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http://linked.open...n/vavai/riv/zamer
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number of pages
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http://purl.org/ne...btex#hasPublisher
| - Institute of Organic Chemistry and Biochemistry ASCR
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https://schema.org/isbn
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