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Description
  • Byla vyvinuta modulární metodika pro přípravu různě substituovaných aryl C-2´-deoxyribonukleosidů. V každé sérii byla vypracována syntetická metodika pro multi-gramovou přípravu klíčového halogenovaného intermediátu, který byl následně přetransformován pomocí cross-coupling reakcí na příslušné alkyl, aryl a amino substituované deriváty. Následné odchránění poskytlo požadované volné C-2´-deoxyribonukleosidy. Tato metodika byla aplikována pro modulární syntézu 4- nebo 3-substituovaných benzen C-nukleosidů, 6-substituovaných pyridin-2-yl C-nukleosidů, 6-substituovaných pyridin-3-yl C-nukleosidů a 5-substituovaných thiofen-2-yl C-nukleosidů. (cs)
  • A modular methodology for the syntheses of various substituted aryl C-2´-deoxyribonucleosides has been developed. In each series, a larger scale synthesis of a versatile halogenated C-nucleoside intermediate has been accomplished, followed by its use for a generation of diverse derivatives by displacement of the halogen for alkyl, aryl or amino substituents by cross-coupling or amination reactions. Subsequent deprotection gave the final desired C-2´-deoxyribonucleosides. This methodology has been applied for the development of modular syntheses of 4- or 3-substituted benzene C-nucleosides, 6-substituted pyridin-2-yl C-nucleosides, 6-substituted pyridin-3-yl C-nucleosides and 5-substituted thiophen-2-yl C-nucleosides.
  • A modular methodology for the syntheses of various substituted aryl C-2´-deoxyribonucleosides has been developed. In each series, a larger scale synthesis of a versatile halogenated C-nucleoside intermediate has been accomplished, followed by its use for a generation of diverse derivatives by displacement of the halogen for alkyl, aryl or amino substituents by cross-coupling or amination reactions. Subsequent deprotection gave the final desired C-2´-deoxyribonucleosides. This methodology has been applied for the development of modular syntheses of 4- or 3-substituted benzene C-nucleosides, 6-substituted pyridin-2-yl C-nucleosides, 6-substituted pyridin-3-yl C-nucleosides and 5-substituted thiophen-2-yl C-nucleosides. (en)
Title
  • Modular methodology for the synthesis of various aryl C-2'-deoxyribonucleosides
  • Modular methodology for the synthesis of various aryl C-2'-deoxyribonucleosides (en)
  • Modulární metodiky pro přípravu různých aryl C-2'-deoxyribonukleosidů (cs)
skos:prefLabel
  • Modular methodology for the synthesis of various aryl C-2'-deoxyribonucleosides
  • Modular methodology for the synthesis of various aryl C-2'-deoxyribonucleosides (en)
  • Modulární metodiky pro přípravu různých aryl C-2'-deoxyribonukleosidů (cs)
skos:notation
  • RIV/61388963:_____/08:00309902!RIV09-AV0-61388963
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(LC512), Z(AV0Z40550506)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 380263
http://linked.open...ai/riv/idVysledku
  • RIV/61388963:_____/08:00309902
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • modular methodology; C-2'-deoxyribonucleosides; benzene; pyridin; thiophenyl (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [DF7EEC16AB62]
http://linked.open...v/mistoKonaniAkce
  • Český Krumlov
http://linked.open...i/riv/mistoVydani
  • Praha
http://linked.open...i/riv/nazevZdroje
  • Chemistry of Nucleic Acid Components
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Bárta, Jan
  • Hocek, Michal
  • Joubert, Nicolas
  • Urban, Milan
http://linked.open...vavai/riv/typAkce
http://linked.open...ain/vavai/riv/wos
  • 000257885700026
http://linked.open.../riv/zahajeniAkce
http://linked.open...n/vavai/riv/zamer
number of pages
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  • Institute of Organic Chemistry and Biochemistry ASCR
https://schema.org/isbn
  • 978-80-86241-29-6
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