About: Human N6-Methyl-AMP/dAMP aminohydrolase (abacavir 5’-monophosphate deaminase) is capable of metabolizing N6-substituted purine acyclic nucleoside phosphonates

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About: Human N6-Methyl-AMP/dAMP aminohydrolase (abacavir 5’-monophosphate deaminase) is capable of metabolizing N6-substituted purine acyclic nucleoside phosphonates Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Recombinant human abacavir monophosphate deaminase (hABC-MP deaminase) efficiently catalyzes the hydrolytic deamination of natural substrates meAMP, and acyclic nucleoside phosphonates (ANP) N6-cyclopropyl-2,6-diamino-9-[2-(phosphonomethoxy)ethyl]purine (cPrPMEDAP), an intermediate intracellular metabolite of antileukemic agent GS-9219. Recombinant human abacavir monophosphate deaminase (hABC-MP deaminase) efficiently catalyzes the hydrolytic deamination of natural substrates meAMP, and acyclic nucleoside phosphonates (ANP) N6-cyclopropyl-2,6-diamino-9-[2-(phosphonomethoxy)ethyl]purine (cPrPMEDAP), an intermediate intracellular metabolite of antileukemic agent GS-9219. (en) Rekombinantní lidská N6-Methyl-AMP/dAMP aminohydrolasa účině katalyzuje hydrolytickou deaminaci přirozeného substrátu meAMP a acyklického nukleosidfosfonátu N6-cyklopropyl-2,6-diamino-9-[2-(fosfonomethoxy)ethyl]purinu (cPrPMEDAP), intracelulárního metabolitu antileukemického agens GS-9219. (cs)
Title	Human N6-Methyl-AMP/dAMP aminohydrolase (abacavir 5’-monophosphate deaminase) is capable of metabolizing N6-substituted purine acyclic nucleoside phosphonates Human N6-Methyl-AMP/dAMP aminohydrolase (abacavir 5’-monophosphate deaminase) is capable of metabolizing N6-substituted purine acyclic nucleoside phosphonates (en) Lidská N6-Methyl-AMP/dAMP aminohydrolasa (abakavir-5’-monofosfátdeaminasa) metabolisuje N6-substitutuované purinové acyklické nucleosidfosfonáty (cs)
skos:prefLabel	Human N6-Methyl-AMP/dAMP aminohydrolase (abacavir 5’-monophosphate deaminase) is capable of metabolizing N6-substituted purine acyclic nucleoside phosphonates Human N6-Methyl-AMP/dAMP aminohydrolase (abacavir 5’-monophosphate deaminase) is capable of metabolizing N6-substituted purine acyclic nucleoside phosphonates (en) Lidská N6-Methyl-AMP/dAMP aminohydrolasa (abakavir-5’-monofosfátdeaminasa) metabolisuje N6-substitutuované purinové acyklické nucleosidfosfonáty (cs)
skos:notation	RIV/61388963:_____/08:00306936!RIV08-AV0-61388963
http://linked.open.../vavai/riv/strany	275;291
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0508), P(1QS400550501), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Votruba, Ivan Holý, Antonín Schinkmanová, Markéta
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	370888
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/08:00306936
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	guanine; acyclic nucleoside phosphonates; cPrPMEDAP; abacavir 5'-phosphate (en)
http://linked.open.../riv/klicoveSlovo	guanine acyclic nucleoside phosphonates abacavir 5'-phosphate cPrPMEDAP
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[2AB297B4D10B]
http://linked.open...i/riv/nazevZdroje	Collection of Czechoslovak Chemical Communications
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	New Antivirals and Antineoplastics Novel antivirals and antineoplastics
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	73
http://linked.open...iv/tvurceVysledku	Holý, Antonín Votruba, Ivan Liu, X. Han, B. Schinkmanová, Markéta Cihlař, T. Shibata, R.
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	0010-0765
number of pages	16 (xsd:int)

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