About: Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Extracellular part of human glutamate carboxypeptidase II was co-crystallized with the phosphapeptide analogs of the enzyme substrates folyl-gamma-glutamate, aspartyl-glutamate, and gamma-glutamyl-glutamate. The determination of the crystal structures allowed us to describe the S1 site of the enzyme in detail for the first time and the corresponding enzyme-ligand interactions, too. Biochemical experiments provided additional information about the influence of the nature of the fragment in the P1 position of the substrate on the hydrolysis rate. Extracellular part of human glutamate carboxypeptidase II was co-crystallized with the phosphapeptide analogs of the enzyme substrates folyl-gamma-glutamate, aspartyl-glutamate, and gamma-glutamyl-glutamate. The determination of the crystal structures allowed us to describe the S1 site of the enzyme in detail for the first time and the corresponding enzyme-ligand interactions, too. Biochemical experiments provided additional information about the influence of the nature of the fragment in the P1 position of the substrate on the hydrolysis rate. (en) Extracelulární část lidské glutamátkarboxypeptidasy II byla vykrystalizována v komplexu s fosfapeptidovými analogy jejích substrátů folyl-gamma-glutamátu, aspartyl-glutamátu a gamma-glutamyl-glutamátu. Rentgenostrukturní analýza umožnila poprvé detailně popsat S1 podmísto enzymu a příslušné interakce s ligandem. Další informace o vlivu druhu fragmentu v P1 pozici substrátu na hydrolýzu poskytla doplňující biochemická měření. (cs)
Title	Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs Strukturální podstata interakcí lidské glutamát karboxypeptidasy II a analogů jejích substrátů (cs) Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs (en)
skos:prefLabel	Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs Strukturální podstata interakcí lidské glutamát karboxypeptidasy II a analogů jejích substrátů (cs) Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs (en)
skos:notation	RIV/61388963:_____/08:00306830!RIV08-AV0-61388963
http://linked.open.../vavai/riv/strany	1438;1450
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0508), Z(AV0Z40550506), Z(MSM 113100001)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Rovenská, Miroslava Konvalinka, Jan Hlouchová, Klára
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	397761
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/08:00306830
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	prostate-specific membrane antigen; metallopeptidase; folate hydrolase; NAALADase; phosphapeptide (en)
http://linked.open.../riv/klicoveSlovo	phosphapeptide metallopeptidase prostate-specific membrane antigen NAALADase folate hydrolase
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[D4BC3ACC3345]
http://linked.open...i/riv/nazevZdroje	Journal of Molecular Biology
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	New Antivirals and Antineoplastics
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	376
http://linked.open...iv/tvurceVysledku	Konvalinka, Jan Lubkowski, J. Hlouchová, Klára Rovenská, Miroslava Slusher, B. S. Tsukamoto, T. Bařinka, C. Dauter, M. Hin, N. Ko, Y. S. Majer, P.
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20113100001
issn	0022-2836
number of pages	13 (xsd:int)

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