Description
| - Disclosed is a compound of formula (I) wherein: R1 is H, amino or methylsulfanyl, R2 is H, methyl, halo,-N(R5)2, hydroxyl, protected hydroxyl or a group of the formula (Ia): R3 is independently H, methyl, hydroxymethyl, halomethyl, or protected hydroxymethyl, R4 is H or halo, Xindependently is O, S or a bond, Z independently is hydroxyl, an ester or amide, R5 is independently H, C1-C8 alkyl or a protecting group, and designates a chiral carbon atom. Also disclosed is a method of preparing compounds of formula (I). Compounds of the type disclosed are useful in the treatment of viral infections.
- Disclosed is a compound of formula (I) wherein: R1 is H, amino or methylsulfanyl, R2 is H, methyl, halo,-N(R5)2, hydroxyl, protected hydroxyl or a group of the formula (Ia): R3 is independently H, methyl, hydroxymethyl, halomethyl, or protected hydroxymethyl, R4 is H or halo, Xindependently is O, S or a bond, Z independently is hydroxyl, an ester or amide, R5 is independently H, C1-C8 alkyl or a protecting group, and designates a chiral carbon atom. Also disclosed is a method of preparing compounds of formula (I). Compounds of the type disclosed are useful in the treatment of viral infections. (en)
- Zveřejňuje se látka vzorce (I), kde R1 je H, amino nebo methamsulfanyl, R2 je H, methyl, halogen, chráněný hydroxyl nebo skupina vzorce (Ia), R3 je nezávisle H, methyl, hydroxymethyl, halomethyl nebo chráněný hydroxymethyl, R4 je H nebo halogen, X je nezávisle O, S nebo vazba, Z je nezávisle hydroxyl, ester nebo amid; R5 je nezávisle H, C1-C18 alkyl nebo chránící skupina, a označuje chirální uhlíkový atom. Je zveřejněna také metoda přípravy látky vzorce (I). Sloučeniny uveřejněného typu jsou použitelné pro léčbu virových infekcí. (cs)
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