About: 6- '2-(phosphonomethoxy)alkoxy pyrimidine derivatives having antiviral activity

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Disclosed is a compound of formula (I) wherein: R1 is H, amino or methylsulfanyl, R2 is H, methyl, halo,-N(R5)2, hydroxyl, protected hydroxyl or a group of the formula (Ia): R3 is independently H, methyl, hydroxymethyl, halomethyl, or protected hydroxymethyl, R4 is H or halo, Xindependently is O, S or a bond, Z independently is hydroxyl, an ester or amide, R5 is independently H, C1-C8 alkyl or a protecting group, and designates a chiral carbon atom. Also disclosed is a method of preparing compounds of formula (I). Compounds of the type disclosed are useful in the treatment of viral infections. Disclosed is a compound of formula (I) wherein: R1 is H, amino or methylsulfanyl, R2 is H, methyl, halo,-N(R5)2, hydroxyl, protected hydroxyl or a group of the formula (Ia): R3 is independently H, methyl, hydroxymethyl, halomethyl, or protected hydroxymethyl, R4 is H or halo, Xindependently is O, S or a bond, Z independently is hydroxyl, an ester or amide, R5 is independently H, C1-C8 alkyl or a protecting group, and designates a chiral carbon atom. Also disclosed is a method of preparing compounds of formula (I). Compounds of the type disclosed are useful in the treatment of viral infections. (en) Zveřejňuje se látka vzorce (I), kde R1 je H, amino nebo methamsulfanyl, R2 je H, methyl, halogen, chráněný hydroxyl nebo skupina vzorce (Ia), R3 je nezávisle H, methyl, hydroxymethyl, halomethyl nebo chráněný hydroxymethyl, R4 je H nebo halogen, X je nezávisle O, S nebo vazba, Z je nezávisle hydroxyl, ester nebo amid; R5 je nezávisle H, C1-C18 alkyl nebo chránící skupina, a označuje chirální uhlíkový atom. Je zveřejněna také metoda přípravy látky vzorce (I). Sloučeniny uveřejněného typu jsou použitelné pro léčbu virových infekcí. (cs)
Title	6- '2-(phosphonomethoxy)alkoxy pyrimidine derivatives having antiviral activity 6- '2-(Phosphonomethoxy)alkoxypyrimidinové deriváty mající protivirovou aktivitu (cs) 6- '2-(phosphonomethoxy)alkoxy pyrimidine derivatives having antiviral activity (en)
skos:prefLabel	6- '2-(phosphonomethoxy)alkoxy pyrimidine derivatives having antiviral activity 6- '2-(Phosphonomethoxy)alkoxypyrimidinové deriváty mající protivirovou aktivitu (cs) 6- '2-(phosphonomethoxy)alkoxy pyrimidine derivatives having antiviral activity (en)
skos:notation	RIV/61388963:_____/07:00309779!RIV08-AV0-61388963
http://linked.open...tracePatentuVzoru	2006-09-29 (xsd:date)
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z4055905)
http://linked.open...cisloPatentuVzoru	NZ530685
http://linked.open...eleniPatentuVzoru	2007-02-11 (xsd:date)
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Holý, Antonín
http://linked.open.../riv/druhVysledku	P - Patent
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	463372
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/07:00309779
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	phosphonomethyl derivatives; open-ring analogues; antivirals (en)
http://linked.open.../riv/klicoveSlovo	antivirals open-ring analogues phosphonomethyl derivatives
http://linked.open...ontrolniKodProRIV	[33D2125BCC2E]
http://linked.open.../licencniPoplatek	A - Poskytovatel licence na výsledek požaduje licenční poplatek
http://linked.open...ydaniPatentuVzoru	Wellington
http://linked.open...atelePatentuVzoru	Intellectual Property Office of New Zealand
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2007
http://linked.open...ydaniPatentuVzoru	NZ - Nový Zéland
http://linked.open...iv/tvurceVysledku	Balzarini, J. Holý, Antonín De Clercq, E.
http://linked.open...mniOchranaPatentu	D - Národní patentový úřad mimo ČR
http://linked.open...avai/riv/vlastnik	Ústav organické chemie a biochemie AV ČR
http://linked.open...itiJinymSubjektem	A - Nabytí licence je nutné vždy
http://linked.open...uzitiPatentuVzoru	B - Využívaný třetí stranou na základě licenční smlouvy
http://linked.open...n/vavai/riv/zamer	Chemical principles of selected biological phenomena in medicine and ecology
http://linked.open...stnikPatentuVzoru	Ústav organické chemie a biochemie AV ČR

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