About: Syntheses of pyrimidine acyclic nucleoside phosphonates as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
Description
  • We synthesized a series of pyrimidine acyclic nucleoside phosphonates bearing of substitutents in C-5 position of uracil moiety and in the N-1-side chain. In addition, we have investigated in particular the novel syntheses of some fluorinated derivatives substituted in the N-1-side chain and uracil C-5 position because fluorine-containing substituents are often powerful modifiers of chemical and biological properties. The obtained compounds exhibit a considerable inhibitory potency of thymidine phosphorylase from SD-lymphoma. In contrast, the synthesized phosphonates are not efficient inhibitors of E. coli and human thymidine phosphorylase.
  • We synthesized a series of pyrimidine acyclic nucleoside phosphonates bearing of substitutents in C-5 position of uracil moiety and in the N-1-side chain. In addition, we have investigated in particular the novel syntheses of some fluorinated derivatives substituted in the N-1-side chain and uracil C-5 position because fluorine-containing substituents are often powerful modifiers of chemical and biological properties. The obtained compounds exhibit a considerable inhibitory potency of thymidine phosphorylase from SD-lymphoma. In contrast, the synthesized phosphonates are not efficient inhibitors of E. coli and human thymidine phosphorylase. (en)
  • Připravili jsme sérii pyrimidinových acyklických nukleosidových fosfonátů obsahujících substituenty v C-5-pozici uracilové části a v N-1-postranním řetězci. Kromě toho jsme studovali nové syntézy některých fluorovaných derivátů substituovaných v N-1-postranním řetězci a C-5-pozici uracilu, neboť substituenty obsahující fluor často významně modifikují chemické a biologické vlastnosti. Získané látky se vyznačují výrazným inhibičnímí účinky vůči thymidinfosforylase z SD-lymfomu. Naopak syntetizované fosfonáty nejsou učinnými inhibitory E.Coli a lidské thymidinfosforylasy. (cs)
Title
  • Syntheses of pyrimidine acyclic nucleoside phosphonates as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma
  • Syntézy pyrimidinových acyklických nukleosidových fosfonátů jako silných inhibitorů tymidin fosforylasy (PD-ECGF) z SD-lymfomu (cs)
  • Syntheses of pyrimidine acyclic nucleoside phosphonates as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma (en)
skos:prefLabel
  • Syntheses of pyrimidine acyclic nucleoside phosphonates as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma
  • Syntézy pyrimidinových acyklických nukleosidových fosfonátů jako silných inhibitorů tymidin fosforylasy (PD-ECGF) z SD-lymfomu (cs)
  • Syntheses of pyrimidine acyclic nucleoside phosphonates as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma (en)
skos:notation
  • RIV/61388963:_____/07:00098779!RIV08-AV0-61388963
http://linked.open.../vavai/riv/strany
  • 1025;1028
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1M0508), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika
  • 8/9
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 453870
http://linked.open...ai/riv/idVysledku
  • RIV/61388963:_____/07:00098779
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • acyclic nucleoside phosphonates; thymidine phosphorylase; pyrimidines; FPMP derivatives; fluorination (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [AF28E32CC169]
http://linked.open...i/riv/nazevZdroje
  • Nucleosides Nucleotides & Nucleic Acids
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 26
http://linked.open...iv/tvurceVysledku
  • Holý, Antonín
  • Pohl, Radek
  • Votruba, Ivan
  • Pomeisl, Karel
http://linked.open...n/vavai/riv/zamer
issn
  • 1525-7770
number of pages
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 81 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software