About: Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase     Goto   Sponge   NotDistinct   Permalink

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Description
  • Zjistili jsme, že 6-halogenované uracily substituované v pozici C5 určitými hydrofobními skupinami vykazují významnou inhibiční aktivitu vůči lidské thymidin fosforylase. Nejúčinnější látky nesou pěti nebo šestičlenný cyklický substituent v poloze C5 a atom chloru v poloze C6. (cs)
  • We have discovered that 6-halouracils substituted at position C5 by certain hydrophobic groups exhibit significant inhibitory activity against human thymidine phosphorylase. The most potent compounds bear a five- or six-membered cyclic substituent at C5 and a chlorine atom attached at C6.
  • We have discovered that 6-halouracils substituted at position C5 by certain hydrophobic groups exhibit significant inhibitory activity against human thymidine phosphorylase. The most potent compounds bear a five- or six-membered cyclic substituent at C5 and a chlorine atom attached at C6. (en)
Title
  • Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase
  • Objev 5-substituovaných-6-chloruracilů jako účinných inhibitorů lidské thymidin fosforylasy (cs)
  • Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase (en)
skos:prefLabel
  • Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase
  • Objev 5-substituovaných-6-chloruracilů jako účinných inhibitorů lidské thymidin fosforylasy (cs)
  • Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase (en)
skos:notation
  • RIV/61388963:_____/07:00091950!RIV08-AV0-61388963
http://linked.open.../vavai/riv/strany
  • 6016;6023
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1M0508), P(1QS400550501), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika
  • 24
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 417487
http://linked.open...ai/riv/idVysledku
  • RIV/61388963:_____/07:00091950
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • thymidine phosphorylase inhibitors (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [B99B61418008]
http://linked.open...i/riv/nazevZdroje
  • Journal of Medicinal Chemistry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 50
http://linked.open...iv/tvurceVysledku
  • Holý, Antonín
  • Hřebabecký, Hubert
  • Jansa, Petr
  • Nencka, Radim
  • Votruba, Ivan
  • Tloušťová, Eva
  • Masojídková, Milena
  • Horská, Květoslava
http://linked.open...n/vavai/riv/zamer
issn
  • 0022-2623
number of pages
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