About: Brassinolide activities of 2alpha,3alpha-diols versus 3alpha,4alpha-diols in the bean second internode bioassay: Explanation by molecular modeling methods

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About: Brassinolide activities of 2alpha,3alpha-diols versus 3alpha,4alpha-diols in the bean second internode bioassay: Explanation by molecular modeling methods Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In general, the structural requirements postulated for a high brassinolide activity are: 2alpha,3alpha-diol, 6-ketone or better 7-oxalactone in B-ring, A/B trans fused ring function, a cis C-22,C-23-diol preferentially with RR configurations, and a C-24 methyl or ethyl substituent. We found that the 3alpha,4alpha-diols 4,6 and 8are more active than the 2alpha,3alpha-diols 3,5 and 7. This fact is in strong contrast with the structure requirements mentioned above. 3D-SAR computer methodologies as alignments and overlaps of GRID maps and 3D-QSAR analysis GRID-GOLPE (CoMFA-like) were used as an effort to explain the higher bioactivity of 3alpha,4alpha-diols 4, 6 and 8 in comparison with the 2alpha,3alpha-diols 3,5 and 7 of B-ring enlarged brassinosteroids. In general, the structural requirements postulated for a high brassinolide activity are: 2alpha,3alpha-diol, 6-ketone or better 7-oxalactone in B-ring, A/B trans fused ring function, a cis C-22,C-23-diol preferentially with RR configurations, and a C-24 methyl or ethyl substituent. We found that the 3alpha,4alpha-diols 4,6 and 8are more active than the 2alpha,3alpha-diols 3,5 and 7. This fact is in strong contrast with the structure requirements mentioned above. 3D-SAR computer methodologies as alignments and overlaps of GRID maps and 3D-QSAR analysis GRID-GOLPE (CoMFA-like) were used as an effort to explain the higher bioactivity of 3alpha,4alpha-diols 4, 6 and 8 in comparison with the 2alpha,3alpha-diols 3,5 and 7 of B-ring enlarged brassinosteroids. (en) Zjistili jsme, že aktivita 2alpha,3alpha-diolů při srovnání s 3alpha,4alpha-diolů v biotestu na druhém internodu fazole odporují dosavadním znalostem v literatuře: poslední uvedené mají vyšší biologickou aktivitu. Práce se pokouší vysvětlit tyto aktivity pomocí molekulového modelování na základě 3D-SAR, 3D-QSAR a GRID mapování. (cs)
Title	Brassinolide activities of 2alpha,3alpha-diols versus 3alpha,4alpha-diols in the bean second internode bioassay: Explanation by molecular modeling methods Brassinolidní aktivity 2alpha,3alpha-diolů při srovnávání s 3alpha,4alpha-diolu v biotestu na druhém internodu fazole: vysvětlení pomocí způsobů molekulového modelování (cs) Brassinolide activities of 2alpha,3alpha-diols versus 3alpha,4alpha-diols in the bean second internode bioassay: Explanation by molecular modeling methods (en)
skos:prefLabel	Brassinolide activities of 2alpha,3alpha-diols versus 3alpha,4alpha-diols in the bean second internode bioassay: Explanation by molecular modeling methods Brassinolidní aktivity 2alpha,3alpha-diolů při srovnávání s 3alpha,4alpha-diolu v biotestu na druhém internodu fazole: vysvětlení pomocí způsobů molekulového modelování (cs) Brassinolide activities of 2alpha,3alpha-diols versus 3alpha,4alpha-diols in the bean second internode bioassay: Explanation by molecular modeling methods (en)
skos:notation	RIV/61388963:_____/07:00091699!RIV08-AV0-61388963
http://linked.open.../vavai/riv/strany	740;750
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M06030), P(1QS510680561), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	11/12
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Kohout, Ladislav Šiša, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	412229
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/07:00091699
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	3D-SAR; 3D-QSAR; biologically active steroids; brassinosteroids (en)
http://linked.open.../riv/klicoveSlovo	3D-QSAR 3D-SAR brassinosteroids biologically active steroids
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[975023BEF3B8]
http://linked.open...i/riv/nazevZdroje	Steroids
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	New preparations for plant growth regulation Functional genomics and proteomics for crop improvement
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	72
http://linked.open...iv/tvurceVysledku	Kohout, Ladislav Šíša, Miroslav Ballesteros, C. B. Vilaplana-Polo, M.
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	0039-128X
number of pages	11 (xsd:int)

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