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rdf:type
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Description
| - In general, the structural requirements postulated for a high brassinolide activity are: 2alpha,3alpha-diol, 6-ketone or better 7-oxalactone in B-ring, A/B trans fused ring function, a cis C-22,C-23-diol preferentially with RR configurations, and a C-24 methyl or ethyl substituent. We found that the 3alpha,4alpha-diols 4,6 and 8are more active than the 2alpha,3alpha-diols 3,5 and 7. This fact is in strong contrast with the structure requirements mentioned above. 3D-SAR computer methodologies as alignments and overlaps of GRID maps and 3D-QSAR analysis GRID-GOLPE (CoMFA-like) were used as an effort to explain the higher bioactivity of 3alpha,4alpha-diols 4, 6 and 8 in comparison with the 2alpha,3alpha-diols 3,5 and 7 of B-ring enlarged brassinosteroids.
- In general, the structural requirements postulated for a high brassinolide activity are: 2alpha,3alpha-diol, 6-ketone or better 7-oxalactone in B-ring, A/B trans fused ring function, a cis C-22,C-23-diol preferentially with RR configurations, and a C-24 methyl or ethyl substituent. We found that the 3alpha,4alpha-diols 4,6 and 8are more active than the 2alpha,3alpha-diols 3,5 and 7. This fact is in strong contrast with the structure requirements mentioned above. 3D-SAR computer methodologies as alignments and overlaps of GRID maps and 3D-QSAR analysis GRID-GOLPE (CoMFA-like) were used as an effort to explain the higher bioactivity of 3alpha,4alpha-diols 4, 6 and 8 in comparison with the 2alpha,3alpha-diols 3,5 and 7 of B-ring enlarged brassinosteroids. (en)
- Zjistili jsme, že aktivita 2alpha,3alpha-diolů při srovnání s 3alpha,4alpha-diolů v biotestu na druhém internodu fazole odporují dosavadním znalostem v literatuře: poslední uvedené mají vyšší biologickou aktivitu. Práce se pokouší vysvětlit tyto aktivity pomocí molekulového modelování na základě 3D-SAR, 3D-QSAR a GRID mapování. (cs)
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Title
| - Brassinolide activities of 2alpha,3alpha-diols versus 3alpha,4alpha-diols in the bean second internode bioassay: Explanation by molecular modeling methods
- Brassinolidní aktivity 2alpha,3alpha-diolů při srovnávání s 3alpha,4alpha-diolu v biotestu na druhém internodu fazole: vysvětlení pomocí způsobů molekulového modelování (cs)
- Brassinolide activities of 2alpha,3alpha-diols versus 3alpha,4alpha-diols in the bean second internode bioassay: Explanation by molecular modeling methods (en)
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skos:prefLabel
| - Brassinolide activities of 2alpha,3alpha-diols versus 3alpha,4alpha-diols in the bean second internode bioassay: Explanation by molecular modeling methods
- Brassinolidní aktivity 2alpha,3alpha-diolů při srovnávání s 3alpha,4alpha-diolu v biotestu na druhém internodu fazole: vysvětlení pomocí způsobů molekulového modelování (cs)
- Brassinolide activities of 2alpha,3alpha-diols versus 3alpha,4alpha-diols in the bean second internode bioassay: Explanation by molecular modeling methods (en)
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skos:notation
| - RIV/61388963:_____/07:00091699!RIV08-AV0-61388963
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(1M06030), P(1QS510680561), Z(AV0Z40550506)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61388963:_____/07:00091699
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - 3D-SAR; 3D-QSAR; biologically active steroids; brassinosteroids (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Kohout, Ladislav
- Šíša, Miroslav
- Ballesteros, C. B.
- Vilaplana-Polo, M.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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