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rdf:type
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Description
| - Transformation of HPMP-5-azacytosine to the corresponding cyclic phosphonate and its subsequent treatment with various alkyl bromides or chloromethyl pivalate via intermediary tetrabutylammonium salt was performed. Compared to parent HPMP-5-azaC, an increase of antiviral activity (against DNA viruses) was found for all prepared prodrugs. The most active compound was found to be the hexadecyloxyethyl ester of cyclic HPMP-5-azaC.
- Transformation of HPMP-5-azacytosine to the corresponding cyclic phosphonate and its subsequent treatment with various alkyl bromides or chloromethyl pivalate via intermediary tetrabutylammonium salt was performed. Compared to parent HPMP-5-azaC, an increase of antiviral activity (against DNA viruses) was found for all prepared prodrugs. The most active compound was found to be the hexadecyloxyethyl ester of cyclic HPMP-5-azaC. (en)
- Byla provedena transformace HPMP-5-azacytosinu na cyklický fosfonát a jeho následná reakce s různými alkylbromidy nebo chlormethylpivaloátem přes tetrabutylammoniovou sůl jako intermediát. Ve srovnání s matečným HPMP-5-azaC byl u všech připravených profarmak zaznamenán vzrůst protivirové aktivity (proti DNA virům). Jako nejaktivnější sloučenina se ukázal hexadecyloxyethylester cyklického HPMP-5-azaC. (cs)
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Title
| - Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: Synthesis and antiviral activity
- Esterová profarmaka odvozená od cyklického 1-(S)-[3-hydroxy-2-(fosfonomethoxy)propyl]-5-azacytosinu: syntéza a protivirová aktivita (cs)
- Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: Synthesis and antiviral activity (en)
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skos:prefLabel
| - Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: Synthesis and antiviral activity
- Esterová profarmaka odvozená od cyklického 1-(S)-[3-hydroxy-2-(fosfonomethoxy)propyl]-5-azacytosinu: syntéza a protivirová aktivita (cs)
- Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: Synthesis and antiviral activity (en)
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skos:notation
| - RIV/61388963:_____/07:00090983!RIV08-AV0-61388963
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(1M0508), P(1QS400550501), Z(AV0Z40550506)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61388963:_____/07:00090983
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - acyclic nucleoside phosphonates; antivirals; HPMP-5-azacytosine; alkoxyalkyl ester; hexadecyloxyethyl ester (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Journal of Medicinal Chemistry
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Andrei, G.
- Balzarini, J.
- Holý, Antonín
- Krečmerová, Marcela
- Neyts, J.
- Pohl, Radek
- Snoeck, R.
- De Clercq, E.
- Masojídková, Milena
- Naesens, L.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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