About: Structure-activity relationship of CART (cocaine- and amphetamine-regulated transcript) peptide fragments

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About: Structure-activity relationship of CART (cocaine- and amphetamine-regulated transcript) peptide fragments Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	CART (cocaine- and amphetamine-regulated transcript) peptidy jsou neuropeptidy, které se vyskytují v CNS a v periferii. Ukazujeme zde vazbu na 125I-CART(61-102) na potkaní tumorové buňky dřeně nadledvin PC12 linii, na celých buňkách a na jejich membránách. Tato studie prezentuje syntézu nových fragmentů peptidu CART souvisejících se strukturními smyčkami CART(61–102). Výsledky dokazují, že struktura se třemi S-S můstky je důležité pro zachování plné biologické aktivity CART peptidů. (cs) CART (cocaine- and amphetamine-regulated transcript) peptides are neuropeptides in the central nervous system and periphery.We report specific binding of 125I-CART(61-102) to the rat adrenal pheochromocytoma PC12 cell line, both intact cells and cell membranes. In this study, we present synthesis of several new peptide fragments corresponding to structural loops of CART(61–102).The results showed that a compact structure containing three disulfide bridges is necessary for preservation of full biological activity of CART peptides. CART (cocaine- and amphetamine-regulated transcript) peptides are neuropeptides in the central nervous system and periphery.We report specific binding of 125I-CART(61-102) to the rat adrenal pheochromocytoma PC12 cell line, both intact cells and cell membranes. In this study, we present synthesis of several new peptide fragments corresponding to structural loops of CART(61–102).The results showed that a compact structure containing three disulfide bridges is necessary for preservation of full biological activity of CART peptides. (en)
Title	Structure-activity relationship of CART (cocaine- and amphetamine-regulated transcript) peptide fragments Structure-activity relationship of CART (cocaine- and amphetamine-regulated transcript) peptide fragments (en) Vztah mezi strukturou a aktivitou peptidu CART a jeho fragmentů (cs)
skos:prefLabel	Structure-activity relationship of CART (cocaine- and amphetamine-regulated transcript) peptide fragments Structure-activity relationship of CART (cocaine- and amphetamine-regulated transcript) peptide fragments (en) Vztah mezi strukturou a aktivitou peptidu CART a jeho fragmentů (cs)
skos:notation	RIV/61388963:_____/07:00088888!RIV08-AV0-61388963
http://linked.open.../vavai/riv/strany	1945;1953
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA303/05/0614), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Blokešová, Darja Slaninová, Jiřina Maixnerová, Jana Blechová, Miroslava Maletínská, Lenka Elbert, Tomáš Železná, Blanka Šanda, Miloslav Hlaváček, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	452943
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/07:00088888
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CART peptide; fragments; binding; PC12 cells (en)
http://linked.open.../riv/klicoveSlovo	PC12 cells fragments binding CART peptide
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[04CDFDE07F41]
http://linked.open...i/riv/nazevZdroje	Peptides
http://linked.open...in/vavai/riv/obor	CF
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Central and peripheral pathways underlying feeding-related effects of cocaine and amphetamine regulated transcript (CART) peptides
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	28
http://linked.open...iv/tvurceVysledku	Blechová, Miroslava Elbert, Tomáš Hlaváček, Jan Maixnerová, Jana Maletínská, Lenka Slaninová, Jiřina Železná, Blanka Šanda, Miloslav Blokešová, Darja Kowalczyk, W.
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	0196-9781
number of pages	9 (xsd:int)

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