About: High-performance liquid chromatography and nuclear magnetic resonance study of linear tetrapeptides and octapeptides containing N-methylated amino acid residues

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Chromatographic behavior of a series of N-methylated tetra and octapeptides on a reversed-phase sorbent was studied considering the information obtained on these compounds by NMR spectroscopy. It was found that many studied N-methylated peptides provide broad peaks as a consequence of cis/trans isomerism of the R1-CO-N(CH3)-R2 peptide bond. The extent of the peak spreading depends on the following important factors: the nature of the surrounding amino acid residues, the location of the modified peptide bond within the peptide chain, temperature, and mobile phase flow-rate. Chromatographic behavior of a series of N-methylated tetra and octapeptides on a reversed-phase sorbent was studied considering the information obtained on these compounds by NMR spectroscopy. It was found that many studied N-methylated peptides provide broad peaks as a consequence of cis/trans isomerism of the R1-CO-N(CH3)-R2 peptide bond. The extent of the peak spreading depends on the following important factors: the nature of the surrounding amino acid residues, the location of the modified peptide bond within the peptide chain, temperature, and mobile phase flow-rate. (en) Chování sérií N-methylovaných tetra a oktapeptidů bylo studování pomocí vysokoúčinné kapalinové chromatografie na reverzní fázi a NMR spektroskopie. Bylo prokázáno, že mnoho N-methylovaných peptidů na chromatografii vykazuje široký pík v důsledku cis/trans isomerie R1-CO-N(CH3)-R2 peptidové vazby. Rozsah rozšíření píku závisí na několika faktorech: typem N-methylované aminokyseliny, její pozicí v aminokyselinovém řetězci, teplotou při měření a průtokovou rychlostí mobilní fáze. (cs)
Title	High-performance liquid chromatography and nuclear magnetic resonance study of linear tetrapeptides and octapeptides containing N-methylated amino acid residues High-performance liquid chromatography and nuclear magnetic resonance study of linear tetrapeptides and octapeptides containing N-methylated amino acid residues (en) Vysokoúčinná kapalinová chromatografie a nukleární magnetická resonance lineárních tetrapeptidů a oktapeptidů obsahujících N-methylované aminokyseliny (cs)
skos:prefLabel	High-performance liquid chromatography and nuclear magnetic resonance study of linear tetrapeptides and octapeptides containing N-methylated amino acid residues High-performance liquid chromatography and nuclear magnetic resonance study of linear tetrapeptides and octapeptides containing N-methylated amino acid residues (en) Vysokoúčinná kapalinová chromatografie a nukleární magnetická resonance lineárních tetrapeptidů a oktapeptidů obsahujících N-methylované aminokyseliny (cs)
skos:notation	RIV/61388963:_____/07:00087561!RIV08-AV0-61388963
http://linked.open.../vavai/riv/strany	128;136
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(KJB400550702), P(LC06077), Z(AV0Z40550506), Z(MSM6046137307)
http://linked.open...iv/cisloPeriodika	1/2
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Buděšínský, Miloš Žáková, Lenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	424142
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/07:00087561
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	N-methylated peptides; cis/trans isomerism; fast chromatography; HPLC; NMR spectroscopy (en)
http://linked.open.../riv/klicoveSlovo	NMR spectroscopy HPLC fast chromatography N-methylated peptides cis/trans isomerism
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[5905590E8FA4]
http://linked.open...i/riv/nazevZdroje	Journal of Chromatography A
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Chemical Genetics New full-length analogs of human insulin with modifications in positions B24-B26.
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	1160
http://linked.open...iv/tvurceVysledku	Buděšínský, Miloš Sýkora, D. Žáková, Lenka
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství Physico-chemical methods of analysis and characterization of chemical systems and biosystems
issn	0021-9673
number of pages	9 (xsd:int)

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