About: Pyrimidine acyclic nucleotide analogues with aromatic substituents in C-5 position

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A series of (S)- and (R)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]uracils and cytosines with various aryl or arylmethyl substituents in C-5 position was prepared. (S)-1-[3-Hydroxy-2-(phosphonomethoxy)propyl]-5-phenyluracil and (R)-1-[3-hydroxy-2-(phosphonomethoxy)-propyl]-5-phenylcytosine exhibited activity against some DNA viruses ((HSV-1 and HSV-2, cytomegalovirus and varicella zoster virus), tested in cell cultures. Some of the 5-phenyluracil derivatives possessed inhibitory activity against thymidine phosphorylase from SD-lymphoma. A series of (S)- and (R)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]uracils and cytosines with various aryl or arylmethyl substituents in C-5 position was prepared. (S)-1-[3-Hydroxy-2-(phosphonomethoxy)propyl]-5-phenyluracil and (R)-1-[3-hydroxy-2-(phosphonomethoxy)-propyl]-5-phenylcytosine exhibited activity against some DNA viruses ((HSV-1 and HSV-2, cytomegalovirus and varicella zoster virus), tested in cell cultures. Some of the 5-phenyluracil derivatives possessed inhibitory activity against thymidine phosphorylase from SD-lymphoma. (en) Byla připravena série (S)- a (R)-1-[3-hydroxy-2-(fosfonomethoxy)propyl]uracilů a cytosinů s různými aryl- a arymethylovými substituenty v poloze C-5. (S)-1-[3-Hydroxy-2-(fosfonomethoxy)propyl]-5-fenyluracil and (R)-1-[3-hydroxy-2-(fosfonomethoxy)propyl]-5-fenylcytosin vykazovaly jistou aktivitu proti DNA virům (HSV-1, HSV-2, cytomegalovirus a varicella zoster virus) na buněčných kulturách. Některé 5-fenyluracilové deriváty vykazovaly inhibiční aktivitu vůči thymidinfosforylase z SD-lymfomu. (cs)
Title	Pyrimidine acyclic nucleotide analogues with aromatic substituents in C-5 position Acyklické analogy nukleotidů s aromatickými substituenty v poloze C-5 (cs) Pyrimidine acyclic nucleotide analogues with aromatic substituents in C-5 position (en)
skos:prefLabel	Pyrimidine acyclic nucleotide analogues with aromatic substituents in C-5 position Acyklické analogy nukleotidů s aromatickými substituenty v poloze C-5 (cs) Pyrimidine acyclic nucleotide analogues with aromatic substituents in C-5 position (en)
skos:notation	RIV/61388963:_____/07:00084754!RIV08-AV0-61388963
http://linked.open.../vavai/riv/strany	927;951
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0508), P(1QS400550501), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Krečmerová, Marcela Holý, Antonín Masojídková, Milena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	446065
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/07:00084754
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	antivirals; acyclic nucleoside phosphonates; 5-phenyluracil; HPMPU; HPMPC (en)
http://linked.open.../riv/klicoveSlovo	antivirals HPMPC 5-phenyluracil HPMPU acyclic nucleoside phosphonates
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[2A59376376D0]
http://linked.open...i/riv/nazevZdroje	Collection of Czechoslovak Chemical Communications
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	New Antivirals and Antineoplastics Novel antivirals and antineoplastics
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	72
http://linked.open...iv/tvurceVysledku	Holý, Antonín Krečmerová, Marcela Masojídková, Milena
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	0010-0765
number of pages	25 (xsd:int)

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