About: Labelling of steroid 3-O-sulfates by tritium and their binding to guinea pig cortical cell membranes

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About: Labelling of steroid 3-O-sulfates by tritium and their binding to guinea pig cortical cell membranes Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	3-H Pregnenolone sulfát a 3-alfa-hydroxy-[3-H]pregnanolone sulfát byly připraveny palladiem katalyzovanou reakcí nenasycených prekurzorů s plynným tritiem v methanolu. Vazebné experimenty s tritiem značenými 3-O-sulfáty odhalily neobvyklou koncentrační závislost vazby tritiem značených ligandů na membrány. Namísto očekávaného poklesu membránově vázané radioaktivity se zvyšující se koncentrací neznačeného ligandu docházelo naopak k jejímu růstu. (cs) 3-H Pregnenolone sulfate and 3-alfa-hydroxy-[3-H]pregnanolone sulfate were prepared by palladium catalysed reaction of unsaturated precursors with tritium gas in methanole. Binding experiments with tritiated 3-O-sulfates showed a kind of paradoxical binding, i.e. not only the labelled compounds were not displaced by the nonlabelled ones, but the amount of activity bound to membranes increased with the increasing concentration of the non-labelled compound. 3-H Pregnenolone sulfate and 3-alfa-hydroxy-[3-H]pregnanolone sulfate were prepared by palladium catalysed reaction of unsaturated precursors with tritium gas in methanole. Binding experiments with tritiated 3-O-sulfates showed a kind of paradoxical binding, i.e. not only the labelled compounds were not displaced by the nonlabelled ones, but the amount of activity bound to membranes increased with the increasing concentration of the non-labelled compound. (en)
Title	Labelling of steroid 3-O-sulfates by tritium and their binding to guinea pig cortical cell membranes Labelling of steroid 3-O-sulfates by tritium and their binding to guinea pig cortical cell membranes (en) Značení steroidních 3-O-sulfátů tritiem a jejich vazba na buněčné membrány kortexu morčat (cs)
skos:prefLabel	Labelling of steroid 3-O-sulfates by tritium and their binding to guinea pig cortical cell membranes Labelling of steroid 3-O-sulfates by tritium and their binding to guinea pig cortical cell membranes (en) Značení steroidních 3-O-sulfátů tritiem a jejich vazba na buněčné membrány kortexu morčat (cs)
skos:notation	RIV/61388963:_____/07:00084747!RIV08-AV0-61388963
http://linked.open.../vavai/riv/strany	574;575
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAA4055305), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	5/6
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Slaninová, Jiřina Chodounská, Hana Elbert, Tomáš Šaman, David
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	430371
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/07:00084747
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	tritium; deuterium; tritiated steroid 3-O-sulfates; palladium (en)
http://linked.open.../riv/klicoveSlovo	deuterium tritium palladium tritiated steroid 3-O-sulfates
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[B633E25E60A3]
http://linked.open...i/riv/nazevZdroje	Journal of Labelled Compounds and Radiopharmaceuticals
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Synthetic analogues of neurosteroids with activity on membrane receptors
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	50
http://linked.open...iv/tvurceVysledku	Chodounská, Hana Elbert, Tomáš Slaninová, Jiřina Šaman, David
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	0362-4803
number of pages	2 (xsd:int)

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