About: Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions     Goto   Sponge   NotDistinct   Permalink

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Description
  • Here we describe aspartic proteases Sap9 and Sap10 of Candida albicans, which have structural similarities to yapsins of Saccharomyces cerevisiae. Sap9 and Sap10 are located in the cell membrane or the cell wall. Both proteases are glycosylated, cleave at dibasic or basic processing sites, and have functions in cell surface integrity and cell separation during budding. Deletion of SAP9 and SAP10 genes modified the adhesion properties of C. albicans to epithelial cells. These proteases have a unique role in cellular processes and host-pathogen interactions.
  • Here we describe aspartic proteases Sap9 and Sap10 of Candida albicans, which have structural similarities to yapsins of Saccharomyces cerevisiae. Sap9 and Sap10 are located in the cell membrane or the cell wall. Both proteases are glycosylated, cleave at dibasic or basic processing sites, and have functions in cell surface integrity and cell separation during budding. Deletion of SAP9 and SAP10 genes modified the adhesion properties of C. albicans to epithelial cells. These proteases have a unique role in cellular processes and host-pathogen interactions. (en)
  • Aspartátové proteasy Sap 9 a Sap10 z Candida albicans, které jsou zakotvené v buněčné stěně nebo membráně, jsou strukturně podobné yapsinům ze Saccharomyces cerevisiae. Obě proteasy jsou glykosylované, štěpí substráty v sekvenci za bazickými či dibazickými aminokyselinami a hrají roli v integritě buněčného povrchu a oddělení buněk při pučení. Delece genů SAP9 a SAP10 z genomu kvasinky změnila adhézní vlastnosti C. albicans k epitheliálním buňkám. Obě proteasy mají unikátní roli v buněčných procesech patogenní kvasinky a v její interakci s hostitelskými buňkami. (cs)
Title
  • Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions
  • Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions (en)
  • Proteasy z Candidy albicans zakotvené k buněčné membráně nebo buněčné stěně glykosylfosfatidylovou kotvou jsou nezbytné pro buněčné procesy a interakci mezi patogenem a hostitelem (cs)
skos:prefLabel
  • Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions
  • Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions (en)
  • Proteasy z Candidy albicans zakotvené k buněčné membráně nebo buněčné stěně glykosylfosfatidylovou kotvou jsou nezbytné pro buněčné procesy a interakci mezi patogenem a hostitelem (cs)
skos:notation
  • RIV/61388963:_____/06:00043437!RIV07-AV0-61388963
http://linked.open.../vavai/riv/strany
  • 688;694
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA303/04/0432), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 477197
http://linked.open...ai/riv/idVysledku
  • RIV/61388963:_____/06:00043437
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • GPL; SAP; GFP; BEC (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [E0A5F079D4F7]
http://linked.open...i/riv/nazevZdroje
  • Journal of Biological Chemistry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 281
http://linked.open...iv/tvurceVysledku
  • Pichová, Iva
  • Schäfer, W.
  • Monod, M.
  • Albrecht, A.
  • Felk, A.
  • Groot de, P.
  • Hube, B.
  • Klis, F.
  • MacCallum, D.
  • Naglik, J. R.
  • Odds, F. C.
  • Schaller, M.
http://linked.open...n/vavai/riv/zamer
issn
  • 0021-9258
number of pages
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